Flt3 active human - Analytical Products / Alfa Chemistry

CAT

IAR42411959

Description	recombinant, expressed in baculovirus infected Sf9 cells, ≥80% (SDS-PAGE)
Assay	≥80% (SDS-PAGE)
Form	aqueous solution
Size	10μG
Storage Conditions	−70°C

1

BET Protein Antagonist JQ1 Is Synergistically Lethal With FLT3 Tyrosine Kinase Inhibitor (TKI) and Overcomes Resistance to FLT3-TKI in AML Cells Expressing FLT-ITD

Warren Fiskus, Sunil Sharma, Jun Qi, Bhavin Shah, Santhana G T Devaraj, Christopher Leveque, Bryce P Portier, Swaminathan Iyer, James E Bradner, Kapil N Bhalla

Mol Cancer Ther. 2014 Oct;13(10):2315-27.

PMID: 25053825

1

Pharmacologic Inhibition of STAT5 in Acute Myeloid Leukemia

Bettina Wingelhofer, Barbara Maurer, Elizabeth C Heyes, Abbarna A Cumaraswamy, Angelika Berger-Becvar, Elvin D de Araujo, Anna Orlova, Patricia Freund, Frank Ruge, Jisung Park, Gary Tin, Siawash Ahmar, etc.

Leukemia. 2018 May;32(5):1135-1146.

PMID: 29472718

1

Sorafenib Promotes Graft-Versus-Leukemia Activity in Mice and Humans Through IL-15 Production in FLT3-ITD-mutant Leukemia Cells

Nimitha R Mathew, Francis Baumgartner, Lukas Braun, David O'Sullivan, Simone Thomas, Miguel Waterhouse, Tony A Müller, Kathrin Hanke, Sanaz Taromi, Petya Apostolova, Anna L Illert, Wolfgang Melchinger, etc.

Nat Med. 2018 Mar;24(3):282-291.

PMID: 29431743

1

Structural and Clinical Consequences of Activation Loop Mutations in Class III Receptor Tyrosine Kinases

Lillian R Klug, Jason D Kent, Michael C Heinrich

Pharmacol Ther. 2018 Nov;191:123-134.

PMID: 29964125

1

Validation of ITD Mutations in FLT3 as a Therapeutic Target in Human Acute Myeloid Leukaemia

Catherine C Smith, Qi Wang, Chen-Shan Chin, Sara Salerno, Lauren E Damon, Mark J Levis, Alexander E Perl, Kevin J Travers, Susana Wang, Jeremy P Hunt, Patrick P Zarrinkar, Eric E Schadt, Andrew Kasarskis, etc.

Nature. 2012 Apr 15;485(7397):260-3.

PMID: 22504184

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