Furin Substrate, Fluorogenic - Analytical Products / Alfa Chemistry

CAT	IAR42416001
Molecular Weight	827.93

Description	A fluorogenic substrate for furin, a mammalian homolog of the yeast Kex2 endoprotease (kcat/Km ~ 2 x 10⁴ s⁻¹M⁻¹).
Solubility	water: 10 mg/mL; DMSO: soluble; λem 430-460 nm
Assay	≥95% (HPLC)
Color	white
Form	solid; desiccated; protect from light
Size	5MG
Storage Conditions	-20C

1

A Novel Cell-Based Sensor Detecting the Activity of Individual Basic Proprotein Convertases

Karin Löw, Kornelia Hardes, Chiara Fedeli, Nabil G Seidah, Daniel B Constam, Antonella Pasquato, Torsten Steinmetzer, Alexandre Roulin, Stefan Kunz

FEBS J. 2019 Nov;286(22):4597-4620.

PMID: 31276291

1

An Internally Quenched Fluorogenic Substrate of Prohormone Convertase 1 and Furin Leads to a Potent Prohormone Convertase Inhibitor

F Jean, A Basak, J DiMaio, N G Seidah, C Lazure

Biochem J. 1995 May 1;307 ( Pt 3)(Pt 3):689-95.

PMID: 7741698

1

Internally Quenched Fluorogenic Substrate for Furin

H Angliker, U Neumann, S S Molloy, G Thomas

Anal Biochem. 1995 Jan 1;224(1):409-12.

PMID: 7710100

1

Limitations of Inhibitory Activities of Polyphenols on Furin-Mediated Substrate Processing

J Zhu, J Declercq, J W M Creemers, C Chen, Y Cui, W J M Van de Ven, A J M Vermorken

Curr Med Chem. 2012;19(21):3641-50.

PMID: 22716122

1

Tethering Soluble Meprin α in an Enzyme Complex to the Cell Surface Affects IBD-associated Genes

Florian Peters, Franka Scharfenberg, Cynthia Colmorgen, Fred Armbrust, Rielana Wichert, Philipp Arnold, Barbara Potempa, Jan Potempa, Claus U Pietrzik, Robert Häsler, Philip Rosenstiel, Christoph Becker-Pauly

FASEB J. 2019 Jun;33(6):7490-7504.

PMID: 30916990

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