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GAT228

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For Research Use Only | Not For Clinical Use
CATAP1446648152
CAS1446648-15-2
Molecular Weight342.39
Description≥98% (HPLC)
SolubilityDMSO: 20 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

Enantiomer-specific Positive Allosteric Modulation of CB

Jose Mitjavila, Danielle Yin, Pushkar M Kulkarni, Chiara Zanato, Ganesh A Thakur, Ruth Ross, Iain Greig, Ken Mackie, Alex Straiker

Pharmacol Res. 2018 Mar;129:475-481.

PMID: 29158048

1

Enantiospecific Allosteric Modulation of Cannabinoid 1 Receptor

Robert B Laprairie, Pushkar M Kulkarni, Jeffrey R Deschamps, Melanie E M Kelly, David R Janero, Maria G Cascio, Lesley A Stevenson, Roger G Pertwee, Terrence P Kenakin, Eileen M Denovan-Wright, Ganesh A Thakur

ACS Chem Neurosci. 2017 Jun 21;8(6):1188-1203.

PMID: 28103441

1

Identification of CB1 Receptor Allosteric Sites Using Force-Biased MMC Simulated Annealing and Validation by Structure-Activity Relationship Studies

Dow P Hurst, Sumanta Garai, Pushkar M Kulkarni, Peter C Schaffer, Patricia H Reggio, Ganesh A Thakur

ACS Med Chem Lett. 2019 Jul 10;10(8):1216-1221.

PMID: 31413808

1

Multiple Binding Sites Contribute to the Mechanism of Mixed Agonistic and Positive Allosteric Modulators of the Cannabinoid CB1 Receptor

Noureldin Saleh, Oliver Hucke, Gert Kramer, Esther Schmidt, Florian Montel, Radoslaw Lipinski, Boris Ferger, Timothy Clark, Peter W Hildebrand, Christofer S Tautermann

Angew Chem Int Ed Engl. 2018 Mar 1;57(10):2580-2585.

PMID: 29314474

1

Positive Allosteric Modulation of the Type 1 Cannabinoid Receptor Reduces the Signs and Symptoms of Huntington's Disease in the R6/2 Mouse Model

Robert B Laprairie, Amina M Bagher, Jillian L Rourke, Adel Zrein, Elizabeth A Cairns, Melanie E M Kelly, Christopher J Sinal, Pushkar M Kulkarni, Ganesh A Thakur, Eileen M Denovan-Wright

Neuropharmacology. 2019 Jun;151:1-12.

PMID: 30940536

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