CAS 905281-76-7 GDC-0879 - Analytical Products / Alfa Chemistry

CAT	AP905281767
CAS	905281-76-7
MDL Number	MFCD16875916
Molecular Weight	334.37

Description	≥98% (HPLC)
Solubility	DMSO: 2 mg/mL, clear (warmed)
Assay	≥98% (HPLC)
Color	white to beige
Form	powder
Size	5MG, 25MG
Storage Conditions	2-8°C

1

Antitumor Efficacy of the Novel RAF Inhibitor GDC-0879 Is Predicted by BRAFV600E Mutational Status and Sustained Extracellular Signal-Regulated kinase/mitogen-activated Protein Kinase Pathway Suppression

Klaus P Hoeflich, Sylvia Herter, Janet Tien, Leo Wong, Leanne Berry, Jocelyn Chan, Carol O'Brien, Zora Modrusan, Somasekar Seshagiri, Mark Lackner, Howard Stern, Edna Choo, Lesley Murray, Lori S Friedman, etc.

Cancer Res. 2009 Apr 1;69(7):3042-51.

PMID: 19276360

1

Disposition of GDC-0879, a B-RAF Kinase Inhibitor in Preclinical Species

E F Choo, J P Driscoll, J Feng, B Liederer, E Plise, N Randolph, Y Shin, S Wong, Y Ran

Xenobiotica. 2009 Sep;39(9):700-9.

PMID: 19552528

1

GDC-0879, a BRAF

Jonas Sieber, Nicolas Wieder, Abbe Clark, Manuel Reitberger, Sofia Matan, Jeannine Schoenfelder, Jianming Zhang, Anna Mandinova, Joshua Adam Bittker, Juan Gutierrez, Ozan Aygün, Namrata Udeshi, Steven Carr, etc.

Cell Chem Biol. 2018 Feb 15;25(2):175-184.e4.

PMID: 29249695

1

Pharmacodynamics of 2-[4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridine-4-yl)-1H-pyrazol-1-yl]ethan-1-ol (GDC-0879), a Potent and Selective B-Raf Kinase Inhibitor: Understanding Relationships Between Systemic Concentrations, Phosphorylated Mitogen-Activated Protein Kinase Kinase 1 Inhibition, and Efficacy

Harvey Wong, Marcia Belvin, Sylvia Herter, Klaus P Hoeflich, Lesley J Murray, Leo Wong, Edna F Choo

J Pharmacol Exp Ther. 2009 Apr;329(1):360-7.

PMID: 19147858

1

Validation and Application of a Liquid Chromatography-Tandem Mass Spectrometric Method for the Determination of GDC-0879 and Its Metabolite in Dog Plasma Using Solid Phase Extraction

Bilin Chou, Ryan S Adler, Min Meng, Shaundel Percey, Brian Dean, Cornelis E C A Hop, Young G Shin

J Pharm Biomed Anal. 2012 Nov;70:354-61.

PMID: 22717139

* Products or Services Interested: GDC-0879 (905281-76-7)
* Your question
* Name
* Email
Verification Code