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GGTI-2133

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For Research Use Only | Not For Clinical Use
CATIAR4243361
MDL NumberMFCD07776925
Molecular Weight570.56
InChI KeyFXXUNOYBYJFSRB-UQIIZPHYSA-N
Description≥98% (HPLC), solid
SolubilityDMSO: 25 mg/mL; H2O: insoluble
Assay≥98% (HPLC)
Colorwhite to beige
Formsolid
MP103-118.5 °C
Size1MG, 5MG
Storage Conditions−20°C
1

GGTI-2133, an Inhibitor of Geranylgeranyltransferase, Inhibits Infiltration of Inflammatory Cells Into Airways in Mouse Experimental Asthma

Y Chiba, S Sato, M Misawa

Int J Immunopathol Pharmacol. Oct-Dec 2009;22(4):929-35.

PMID: 20074456

1

Inhibition of Geranylgeranyltransferase Attenuates Neutrophil Accumulation and Tissue Injury in Severe Acute Pancreatitis

Mohammed Merza, Erik Wetterholm, Su Zhang, Sara Regner, Henrik Thorlacius

J Leukoc Biol. 2013 Sep;94(3):493-502.

PMID: 23744643

1

Inhibition of Geranylgeranyltransferase Inhibits Bronchial Smooth Muscle Hyperresponsiveness in Mice

Yoshihiko Chiba, Shunsuke Sato, Motohiko Hanazaki, Hiroyasu Sakai, Miwa Misawa

Am J Physiol Lung Cell Mol Physiol. 2009 Nov;297(5):L984-91.

PMID: 19717551

1

Pharmacological Modulation of Geranylgeranyltransferase and Farnesyltransferase Attenuates Opioid Withdrawal in Vivo and in Vitro

Ashish K Rehni, Thakur Gurjeet Singh

Neuropharmacology. 2013 Aug;71:19-26.

PMID: 23415632

1

Simvastatin and GGTI-2133, a Geranylgeranyl Transferase Inhibitor, Increase Erythrocyte Deformability but Reduce Low O(2) Tension-Induced ATP Release

K M Clapp, M L Ellsworth, R S Sprague, A H Stephenson

Am J Physiol Heart Circ Physiol. 2013 Mar 1;304(5):H660-6.

PMID: 23335799

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