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GKA50

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For Research Use Only | Not For Clinical Use
CATAP851884872
CAS851884-87-2
Molecular Weight464.51
Description≥98% (HPLC)
SolubilityDMSO: 15 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions−20°C
1

Design of a Potent, Soluble Glucokinase Activator With Increased Pharmacokinetic Half-Life

Kurt G Pike, Joanne V Allen, Peter W R Caulkett, David S Clarke, Craig S Donald, Mark L Fenwick, Keith M Johnson, Craig Johnstone, Darren McKerrecher, John W Rayner, Rolf P Walker, Ingrid Wilson

Bioorg Med Chem Lett. 2011 Jun 1;21(11):3467-70.

PMID: 21515051

1

Effects of Glucokinase Activators GKA50 and LY2121260 on Proliferation and Apoptosis in Pancreatic INS-1 Beta Cells

P Wei, M Shi, S Barnum, H Cho, T Carlson, J D Fraser

Diabetologia. 2009 Oct;52(10):2142-50.

PMID: 19641898

1

Glucose Enhances Rat Islet Function via Stimulating CART Expression

Wan Xu, Yuqing Zhang, Mengyao Bai, Feiye Zhou, Ruyuan Deng, Xueying Ji, Juan Zhang, Yun Liu, Libin Zhou, Xiao Wang

Biochem Biophys Res Commun. 2016 Dec 2;481(1-2):84-89.

PMID: 27823935

1

Glucose-dependent Modulation of Insulin Secretion and Intracellular Calcium Ions by GKA50, a Glucokinase Activator

Daniel Johnson, Ruth M Shepherd, Debra Gill, Tracy Gorman, David M Smith, Mark J Dunne

Diabetes. 2007 Jun;56(6):1694-702.

PMID: 17360975

1

The Glucokinase Activator GKA50 Causes an Increase in Cell Volume and Activation of Volume-Regulated Anion Channels in Rat Pancreatic β-cells

Lisa McGlasson, Len Best, Peter D Brown

Mol Cell Endocrinol. 2011 Aug 6;342(1-2):48-53.

PMID: 21664426

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