CAS 281209-71-0 Glucagon-Like Peptide 1 Receptor Agonist - CAS 281209-71-0

CAT	AP281209710
CAS	281209-71-0
Molecular Weight	348.25

Description	The Glucagon-Like Peptide 1 Receptor Agonist, also referenced under CAS 281209-71-0, controls the biological activity of Glucagon-Like Peptide 1 Receptor. This small molecule/inhibitor is primarily used for Cell Signaling applications.
Solubility	ethanol: 10 mg/mL; DMSO: 20 mg/mL
Assay	≥97% (HPLC)
Color	yellow
Form	solid; protect from light
Size	5MG
Storage Conditions	+2C to +8C

1

Activation of the GLP-1 Receptor by a Non-Peptidic Agonist

Peishen Zhao, Yi-Lynn Liang, Matthew J Belousoff, Giuseppe Deganutti, Madeleine M Fletcher, Francis S Willard, Michael G Bell, Michael E Christe, Kyle W Sloop, Asuka Inoue, Tin T Truong, Lachlan Clydesdale, etc.

Nature. 2020 Jan;577(7790):432-436.

PMID: 31915381

1

Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes

Chris de Graaf, Dan Donnelly, Denise Wootten, Jesper Lau, Patrick M Sexton, Laurence J Miller, Jung-Mo Ahn, Jiayu Liao, Madeleine M Fletcher, Dehua Yang, Alastair J H Brown, Caihong Zhou, Jiejie Deng, Ming-Wei Wang

Pharmacol Rev. 2016 Oct;68(4):954-1013.

PMID: 27630114

1

Human GLP-1 Receptor Transmembrane Domain Structure in Complex With Allosteric Modulators

Gaojie Song, Dehua Yang, Yuxia Wang, Chris de Graaf, Qingtong Zhou, Shanshan Jiang, Kaiwen Liu, Xiaoqing Cai, Antao Dai, Guangyao Lin, Dongsheng Liu, Fan Wu, Yiran Wu, Suwen Zhao, Li Ye, Gye Won Han, Jesper Lau, etc.

Nature. 2017 Jun 8;546(7657):312-315.

PMID: 28514449

1

Phase-plate cryo-EM Structure of a Biased Agonist-Bound Human GLP-1 receptor-Gs Complex

Yi-Lynn Liang, Maryam Khoshouei, Alisa Glukhova, Sebastian G B Furness, Peishen Zhao, Lachlan Clydesdale, Cassandra Koole, Tin T Truong, David M Thal, Saifei Lei, Mazdak Radjainia, Radostin Danev, Wolfgang Baumeister, etc.

Nature. 2018 Mar 1;555(7694):121-125.

PMID: 29466332

1

Two Distinct Domains of the Glucagon-Like peptide-1 Receptor Control Peptide-Mediated Biased Agonism

Saifei Lei, Lachlan Clydesdale, Antao Dai, Xiaoqing Cai, Yang Feng, Dehua Yang, Yi-Lynn Liang, Cassandra Koole, Peishen Zhao, Thomas Coudrat, Arthur Christopoulos, Ming-Wei Wang, Denise Wootten, Patrick M Sexton

J Biol Chem. 2018 Jun 15;293(24):9370-9387.

PMID: 29717000

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