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GMX1778

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For Research Use Only | Not For Clinical Use
CATAP200484113
CAS200484-11-3
Structure
Molecular Weight371.86
Description≥98% (HPLC)
SolubilityDMSO: 20 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions−20°C
1

Genotype-targeted Local Therapy of Glioma

Ganesh M Shankar, Ameya R Kirtane, Julie J Miller, Hormoz Mazdiyasni, Jaimie Rogner, Tammy Tai, Erik A Williams, Fumi Higuchi, Tareq A Juratli, Kensuke Tateishi, Mara V A Koerner, Shilpa S Tummala, Alexandria L Fink, etc.

Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):E8388-E8394.

PMID: 30082399

1

Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT) Activity by Small Molecule GMX1778 Regulates Reactive Oxygen Species (ROS)-mediated Cytotoxicity in a p53- And Nicotinic Acid phosphoribosyltransferase1 (NAPRT1)-dependent Manner

David Cerna, Hongyun Li, Siobhan Flaherty, Naoko Takebe, C Norman Coleman, Stephen S Yoo

J Biol Chem. 2012 Jun 22;287(26):22408-17.

PMID: 22570471

1

NAMPT Inhibitor GMX1778 Enhances the Efficacy of 177Lu-DOTATATE Treatment of Neuroendocrine Tumors

Anna-Karin Elf, Peter Bernhardt, Tobias Hofving, Yvonne Arvidsson, Eva Forssell-Aronsson, Bo Wängberg, Ola Nilsson, Viktor Johanson

J Nucl Med. 2017 Feb;58(2):288-292.

PMID: 27688470

1

Preclinical Development of the Nicotinamide Phosphoribosyl Transferase Inhibitor Prodrug GMX1777

Pierre Beauparlant, Dominique Bédard, Cynthia Bernier, Helen Chan, Karine Gilbert, Daniel Goulet, Michel-Olivier Gratton, Manon Lavoie, Anne Roulston, Emilie Turcotte, Mark Watson

Anticancer Drugs. 2009 Jun;20(5):346-54.

PMID: 19369827

1

Targeting Glucose Transport and the NAD Pathway in Tumor Cells With STF-31: A Re-Evaluation

Dominik Kraus, Jan Reckenbeil, Nadine Veit, Stefan Kuerpig, Michael Meisenheimer, Imke Beier, Helmut Stark, Jochen Winter, Rainer Probstmeier

Cell Oncol (Dordr). 2018 Oct;41(5):485-494.

PMID: 29949049

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