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GNF-7

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For Research Use Only | Not For Clinical Use
CATAP839706079
CAS839706-07-9
Structure
Molecular Weight547.53
Description≥98% (HPLC)
SolubilityDMSO: 2 mg/mL, clear (warmed)
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

Discovery of 2-((3-Amino-4-methylphenyl)amino)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-ABL-053) as a Potent, Selective, and Orally Available BCR-ABL/SRC/p38 Kinase Inhibitor for Chronic Myeloid Leukemia

Xiaofei Liang, Xiaochuan Liu, Beilei Wang, Fengming Zou, Aoli Wang, Shuang Qi, Cheng Chen, Zheng Zhao, Wenchao Wang, Ziping Qi, Fengchao Lv, Zhenquan Hu, Li Wang, Shanchun Zhang, Qingsong Liu, Jing Liu

J Med Chem. 2016 Mar 10;59(5):1984-2004.

PMID: 26789553

1

First SAR Study for Overriding NRAS Mutant Driven Acute Myeloid Leukemia

Hanna Cho, Injae Shin, Eunhye Ju, Seunghye Choi, Wooyoung Hur, Haelee Kim, Eunmi Hong, Nam Doo Kim, Hwan Geun Choi, Nathanael S Gray, Taebo Sim

J Med Chem. 2018 Sep 27;61(18):8353-8373.

PMID: 30153003

1

Hybrid Pyrimidine Alkynyls Inhibit the Clinically Resistance Related Bcr-Abl(T315I) Mutant

Xiaoyun Lu, Zhang Zhang, Xiaomei Ren, Xiaofeng Pan, Deping Wang, Xiaoxi Zhuang, Jingfeng Luo, Rongmin Yu, Ke Ding

Bioorg Med Chem Lett. 2015 Sep 1;25(17):3458-63.

PMID: 26195136

1

Identification of Novel Therapeutic Targets in Acute Leukemias With NRAS Mutations Using a Pharmacologic Approach

Atsushi Nonami, Martin Sattler, Ellen Weisberg, Qingsong Liu, Jianming Zhang, Matthew P Patricelli, Amanda L Christie, Amy M Saur, Nancy E Kohl, Andrew L Kung, Hojong Yoon, Taebo Sim, Nathanael S Gray, etc.

Blood. 2015 May 14;125(20):3133-43.

PMID: 25833960

1

The Bcr-Abl Inhibitor GNF-7 Inhibits Necroptosis and Ameliorates Acute Kidney Injury by Targeting RIPK1 and RIPK3 Kinases

Xia Qin, Longmiao Hu, Shen-Nan Shi, Xiaofei Chen, Chunlin Zhuang, Wen Zhang, Siriporn Jitkaew, Xiufeng Pang, Jianqiang Yu, Ye-Xiong Tan, Hong-Yang Wang, Zhenyu Cai

Biochem Pharmacol. 2020 Jul;177:113947.

PMID: 32247850

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