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GRN-529

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For Research Use Only | Not For Clinical Use
CATAP1253291121
CAS1253291-12-1
Structure
MDL NumberMFCD28160551
Molecular Weight391.37
InChI KeyJITMSIRHBAVREW-UHFFFAOYSA-N
Description≥97% (HPLC)
SolubilityDMSO: 5 mg/mL, clear (warmed)
Assay≥97% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditionsroom temp
1

Negative Allosteric Modulation of Metabotropic Glutamate Receptor 5 Results in Broad Spectrum Activity Relevant to Treatment Resistant Depression

Z A Hughes, S J Neal, D L Smith, S J Sukoff Rizzo, C M Pulicicchio, S Lotarski, S Lu, J M Dwyer, J Brennan, M Olsen, C N Bender, E Kouranova, T H Andree, J E Harrison, G T Whiteside, D Springer, S V O'Neil, etc.

Neuropharmacology. 2013 Mar;66:202-14.

PMID: 22551786

1

Negative Allosteric Modulation of the mGluR5 Receptor Reduces Repetitive Behaviors and Rescues Social Deficits in Mouse Models of Autism

Jill L Silverman, Daniel G Smith, Stacey J Sukoff Rizzo, Michael N Karras, Sarah M Turner, Seda S Tolu, Dianne K Bryce, Deborah L Smith, Kari Fonseca, Robert H Ring, Jacqueline N Crawley

Sci Transl Med. 2012 Apr 25;4(131):131ra51.

PMID: 22539775

1

Neurophysiological Signals as Potential Translatable Biomarkers for Modulation of Metabotropic Glutamate 5 Receptors

B D Harvey, C J Siok, T Kiss, D Volfson, S Grimwood, C L Shaffer, M Hajós

Neuropharmacology. 2013 Dec;75:19-30.

PMID: 23831682

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