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GSK-LSD1

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For Research Use Only | Not For Clinical Use
CATALP1431368487
CAS1431368-48-7 (free base)
Molecular Weight289.24
InChI KeyBASFYRLYJAZPPL-UONOGXRCSA-N
Description≥98% (HPLC)
SolubilityH2O: 20 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

Inhibition of LSD1 Epigenetically Attenuates Oral Cancer Growth and Metastasis

Saqer F Alsaqer, Mustafa M Tashkandi, Vinay K Kartha, Ya-Ting Yang, Yazeed Alkheriji, Andrew Salama, Xaralabos Varelas, Maria Kukuruzinska, Stefano Monti, Manish V Bais

Oncotarget. 2017 Jul 27;8(43):73372-73386.

PMID: 29088714

1

LSD1 Inhibition Exerts Its Antileukemic Effect by Recommissioning PU.1- And C/EBPα-dependent Enhancers in AML

Monica Cusan, Sheng F Cai, Helai P Mohammad, Andrei Krivtsov, Alan Chramiec, Evangelia Loizou, Matthew D Witkin, Kimberly N Smitheman, Daniel G Tenen, Min Ye, Britta Will, Ulrich Steidl, Ryan G Kruger, etc.

Blood. 2018 Apr 12;131(15):1730-1742.

PMID: 29453291

1

Lysine specific demethylase 1 inactivation enhances differentiation and promotes cytotoxic response when combined with all- trans retinoic acid in acute myeloid leukemia across subtypes

Kimberly N Smitheman, Tesa M Severson, Satyajit R Rajapurkar, Michael T McCabe, Natalie Karpinich, James Foley, Melissa B Pappalardi, Ashley Hughes, Wendy Halsey, Elizabeth Thomas, Christopher Traini, Kelly E Federowicz, etc.

Haematologica. 2019 Jun;104(6):1156-1167.

PMID: 30514804

1

PKCα-LSD1-NF-κB-Signaling Cascade Is Crucial for Epigenetic Control of the Inflammatory Response

Dongha Kim, Hye Jin Nam, Wonhwa Lee, Hwa Young Yim, Jun-Yeong Ahn, Se Won Park, Hi-Jai R Shin, Reynold Yu, Kyoung-Jae Won, Jong-Sup Bae, Keun Il Kim, Sung Hee Baek

Mol Cell. 2018 Feb 1;69(3):398-411.e6.

PMID: 29395062

1

Therapeutic Targeting of KDM1A/LSD1 in Ewing Sarcoma With SP-2509 Engages the Endoplasmic Reticulum Stress Response

Kathleen I Pishas, Christina D Drenberg, Cenny Taslim, Emily R Theisen, Kirsten M Johnson, Ranajeet S Saund, Ioana L Pop, Brian D Crompton, Elizabeth R Lawlor, Franck Tirode, Jaume Mora, Olivier Delattre, etc.

Mol Cancer Ther. 2018 Sep;17(9):1902-1916.

PMID: 29997151

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