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GSK180736A

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For Research Use Only | Not For Clinical Use
CATAP817194380
CAS817194-38-0
MDL NumberMFCD30533616
Molecular Weight365.36
Description≥98% (HPLC)
SolubilityDMSO: 2 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

A New Paroxetine-Based GRK2 Inhibitor Reduces Internalization of the μ-Opioid Receptor

Renee A Bouley, Zara Y Weinberg, Helen V Waldschmidt, Yu-Chen Yen, Scott D Larsen, Manojkumar A Puthenveedu, John J G Tesmer

Mol Pharmacol. 2020 Jun;97(6):392-401.

PMID: 32234810

1

Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex With a Rationally Designed Inhibitor

Kristoff T Homan, Helen V Waldschmidt, Alisa Glukhova, Alessandro Cannavo, Jianliang Song, Joseph Y Cheung, Walter J Koch, Scott D Larsen, John J G Tesmer

J Biol Chem. 2015 Aug 21;290(34):20649-59.

PMID: 26032411

1

Identification and Structure-Function Analysis of Subfamily Selective G Protein-Coupled Receptor Kinase Inhibitors

Kristoff T Homan, Kelly M Larimore, Jonathan M Elkins, Marta Szklarz, Stefan Knapp, John J G Tesmer

ACS Chem Biol. 2015 Jan 16;10(1):310-9.

PMID: 25238254

1

Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein-Coupled Receptor Kinase 2 Inhibitors

Renee Bouley, Helen V Waldschmidt, M Claire Cato, Alessandro Cannavo, Jianliang Song, Joseph Y Cheung, Xin-Qiu Yao, Walter J Koch, Scott D Larsen, John J G Tesmer

Mol Pharmacol. 2017 Dec;92(6):707-717.

PMID: 29070696

1

Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors

Helen V Waldschmidt, Kristoff T Homan, Osvaldo Cruz-Rodríguez, Marilyn C Cato, Jessica Waninger-Saroni, Kelly M Larimore, Alessandro Cannavo, Jianliang Song, Joseph Y Cheung, Paul D Kirchhoff, Walter J Koch, etc.

J Med Chem. 2016 Apr 28;59(8):3793-807.

PMID: 27050625

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