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GSK2578215A

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For Research Use Only | Not For Clinical Use
CATAP1285515210
CAS1285515-21-0
Molecular Weight399.42
Description≥98% (HPLC)
SolubilityDMSO: 15 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

Increase in Anti-Apoptotic Molecules, Nucleolin, and Heat Shock Protein 70, Against Upregulated LRRK2 Kinase Activity

Jihoon Jang, Hakjin Oh, Daleum Nam, Wongi Seol, Mi Kyoung Seo, Sung Woo Park, Hyung Gun Kim, Hyemyung Seo, Ilhong Son, Dong Hwan Ho

Anim Cells Syst (Seoul). 2018 Sep 12;22(5):273-280.

PMID: 30460108

1

Leucine-rich Repeat Kinase 2 (LRRK2) Inhibitors Differentially Modulate Glutamate Release and Serine935 LRRK2 Phosphorylation in Striatal and Cerebrocortical Synaptosomes

Daniela Mercatelli, Paolo Bolognesi, Martina Frassineti, Clarissa A Pisanò, Francesco Longo, Derya R Shimshek, Michele Morari

Pharmacol Res Perspect. 2019 May 27;7(3):e00484.

PMID: 31149340

1

LRRK2 Impairs Autophagy by Mediating Phosphorylation of leucyl-tRNA Synthetase

Dong Hwan Ho, Hyejung Kim, Daleum Nam, Hyuna Sim, Janghwan Kim, Hyung Gun Kim, Ilhong Son, Wongi Seol

Cell Biochem Funct. 2018 Dec;36(8):431-442.

PMID: 30411383

1

LRRK2 Kinase Activity Induces Mitochondrial Fission in Microglia via Drp1 and Modulates Neuroinflammation

Dong Hwan Ho, A Reum Je, Haejin Lee, Ilhong Son, Hee-Seok Kweon, Hyung-Gun Kim, Wongi Seol

Exp Neurobiol. 2018 Jun;27(3):171-180.

PMID: 30022868

1

LRRK2 Kinase Plays a Critical Role in Manganese-Induced Inflammation and Apoptosis in Microglia

Judong Kim, Edward Pajarillo, Asha Rizor, Deok-Soo Son, Jayden Lee, Michael Aschner, Eunsook Lee

PLoS One. 2019 Jan 15;14(1):e0210248.

PMID: 30645642

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