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GSK2830371

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For Research Use Only | Not For Clinical Use
CATAP1404456536
CAS1404456-53-6
Molecular Weight461.02
Description≥98% (HPLC)
SolubilityDMSO: 20 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in TP53 wild-type Ewing sarcoma

Björn Stolte, Amanda Balboni Iniguez, Neekesh V Dharia, Amanda L Robichaud, Amy Saur Conway, Ann M Morgan, Gabriela Alexe, Nathan J Schauer, Xiaoxi Liu, Gregory H Bird, Aviad Tsherniak, Francisca Vazquez, etc.

J Exp Med. 2018 Aug 6;215(8):2137-2155.

PMID: 30045945

1

Inhibition of WIP1 Phosphatase Sensitizes Breast Cancer Cells to Genotoxic Stress and to MDM2 Antagonist nutlin-3

Sona Pechackova, Kamila Burdova, Jan Benada, Petra Kleiblova, Gabriela Jenikova, Libor Macurek

Oncotarget. 2016 Mar 22;7(12):14458-75.

PMID: 26883108

1

Targeting Negative Regulation of p53 by MDM2 and WIP1 as a Therapeutic Strategy in Cutaneous Melanoma

Chiao-En Wu, Arman Esfandiari, Yi-Hsuan Ho, Nan Wang, Ahmed Khairallah Mahdi, Erhan Aptullahoglu, Penny Lovat, John Lunec

Br J Cancer. 2018 Feb 20;118(4):495-508.

PMID: 29235570

1

The Pathophysiological Significance of PPM1D and Therapeutic Targeting of PPM1D-mediated Signaling by GSK2830371 in Mantle Cell Lymphoma

Kensuke Kojima, Aya Maeda, Mariko Yoshimura, Yuki Nishida, Shinya Kimura

Oncotarget. 2016 Oct 25;7(43):69625-69637.

PMID: 27626308

1

Wip1 Inhibitor GSK2830371 Inhibits Neuroblastoma Growth by Inducing Chk2/p53-mediated Apoptosis

Zhenghu Chen, Long Wang, Dayong Yao, Tianshu Yang, Wen-Ming Cao, Jun Dou, Jonathan C Pang, Shan Guan, Huiyuan Zhang, Yang Yu, Yanling Zhao, Yongfeng Wang, Xin Xu, Yan Shi, Roma Patel, Hong Zhang, Sanjeev A Vasudevan, etc.

Sci Rep. 2016 Dec 19;6:38011.

PMID: 27991505

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