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GV-58

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For Research Use Only | Not For Clinical Use
CATAP1402821413
CAS1402821-41-3
MDL NumberMFCD28385865
Molecular Weight374.50
InChI KeyDPTXJOUVBMUSGY-CYBMUJFWSA-N
Description≥97% (HPLC)
SolubilityDMSO: 20 mg/mL, clear
Assay≥97% (HPLC)
Colorwhite to beige
Formpowder
Size1MG, 5MG
Storage Conditions−20°C
1

A mutation in Ca V 2.1 linked to a severe neurodevelopmental disorder impairs channel gating

Sidharth Tyagi, Tyler R Bendrick, Dilyana Filipova, Symeon Papadopoulos, Roger A Bannister

J Gen Physiol. 2019 Jun 3;151(6):850-859.

PMID: 31015257

1

Complete Reversal of Lambert-Eaton Myasthenic Syndrome Synaptic Impairment by the Combined Use of a K+ Channel Blocker and a Ca2+ Channel Agonist

Tyler B Tarr, David Lacomis, Stephen W Reddel, Mary Liang, Guillermo Valdomir, Michael Frasso, Peter Wipf, Stephen D Meriney

J Physiol. 2014 Aug 15;592(16):3687-96.

PMID: 25015919

1

Evaluation of a Novel Calcium Channel Agonist for Therapeutic Potential in Lambert-Eaton Myasthenic Syndrome

Tyler B Tarr, Waqas Malick, Mary Liang, Guillermo Valdomir, Michael Frasso, David Lacomis, Stephen W Reddel, Adolfo Garcia-Ocano, Peter Wipf, Stephen D Meriney

J Neurosci. 2013 Jun 19;33(25):10559-67.

PMID: 23785168

1

New Cav2 Calcium Channel Gating Modifiers With Agonist Activity and Therapeutic Potential to Treat Neuromuscular Disease

Man Wu, Hayley V White, Blake A Boehm, Christopher J Meriney, Kaylan Kerrigan, Michael Frasso, Mary Liang, Erika M Gotway, Madeleine R Wilcox, Jon W Johnson, Peter Wipf, Stephen D Meriney

Neuropharmacology. 2018 Mar 15;131:176-189.

PMID: 29246857

1

Synaptic Pathophysiology and Treatment of Lambert-Eaton Myasthenic Syndrome

Tyler B Tarr, Peter Wipf, Stephen D Meriney

Mol Neurobiol. 2015 Aug;52(1):456-63.

PMID: 25195700

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