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GW2974

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For Research Use Only | Not For Clinical Use
CATAP202272682
CAS202272-68-2
Structure
MDL NumberMFCD04974495
Molecular Weight395.46
InChI KeyDYYZXRCFCVDSKD-UHFFFAOYSA-N
Description≥98% (HPLC), solid
SolubilityDMSO: ≥20 mg/mL
Assay≥98% (HPLC)
Coloryellow
Formsolid
Size50MG, 250MG
1

Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced Oral Carcinogenesis in Hamster Cheek Pouch by Topical Application of a Dual Inhibitor of Epidermal Growth Factor Receptor (EGFR) and ErbB2 Tyrosine Kinases

Zheng Sun, Sandeep Sood, Ning Li, Peiying Yang, Robert A Newman, Chung S Yang, Xiaoxin Chen

Oral Oncol. 2008 Jul;44(7):652-7.

PMID: 17936675

1

Differential Effects of Low- And High-Dose GW2974, a Dual Epidermal Growth Factor Receptor and HER2 Kinase Inhibitor, on Glioblastoma Multiforme Invasion

Lulu Wang, Qian Liu, Hong Zhao, Kemi Cui, Linli Yao, Fang Nie, Guangxu Jin, Aijun Hao, Stephen T C Wong

J Neurosci Res. 2013 Jan;91(1):128-37.

PMID: 23115024

1

Dual Inhibition of Both the Epidermal Growth Factor Receptor and erbB2 Effectively Inhibits the Promotion of Skin Tumors During Two-Stage Carcinogenesis

Kaoru Kiguchi, Takuya Kitamura, Tricia Moore, Mohammad Rumi, Hsiang-Chun Chang, Devon Treece, Lynnsie Ruffino, Kevin Connolly, John DiGiovanni

Cancer Prev Res (Phila). 2010 Aug;3(8):940-52.

PMID: 20682802

1

Endurance Exercise Training Preserves Cardiac Function in Rats Receiving Doxorubicin and the HER-2 Inhibitor GW2974

Karen Y Wonders, David S Hydock, Stephanie Greufe, Carole M Schneider, Reid Hayward

Cancer Chemother Pharmacol. 2009 Nov;64(6):1105-13.

PMID: 19352663

1

GW583340 and GW2974, Human EGFR and HER-2 Inhibitors, Reverse ABCG2- And ABCB1-mediated Drug Resistance

Kamlesh Sodani, Amit K Tiwari, Satyakam Singh, Atish Patel, Zhi-Jie Xiao, Jun-Jiang Chen, Yue-Li Sun, Tanaji T Talele, Zhe-Sheng Chen

Biochem Pharmacol. 2012 Jun 15;83(12):1613-22.

PMID: 22414725

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