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HA 14-1

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For Research Use Only | Not For Clinical Use
CATAP65673634
CAS65673-63-4
Structure
MDL NumberMFCD00218213
Molecular Weight409.23
InChI KeySXJDCULZDFWMJC-UHFFFAOYSA-N
Description≥95% (CHN/NMR), powder
SolubilityDMSO: 26 mg/mL
Assay≥95% (CHN/NMR)
Formpowder
Size25MG
Storage Conditions−20°C
1

Dual Mechanisms of sHA 14-1 in Inducing Cell Death Through Endoplasmic Reticulum and Mitochondria

David Hermanson, Sadiya N Addo, Anna A Bajer, Jonathan S Marchant, Sonia Goutam Kumar Das, Balasubramanian Srinivasan, Fawaz Al-Mousa, Francesco Michelangeli, David D Thomas, Tucker W Lebien, Chengguo Xing

Mol Pharmacol. 2009 Sep;76(3):667-78.

PMID: 19561125

1

Ethyl-2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H- chromene-3-carboxylate (HA 14-1), a Prototype Small-Molecule Antagonist Against Antiapoptotic Bcl-2 Proteins, Decomposes to Generate Reactive Oxygen Species That Induce Apoptosis

Jignesh M Doshi, Defeng Tian, Chengguo Xing

Mol Pharm. Nov-Dec 2007;4(6):919-28.

PMID: 17874842

1

Naringenin-induced Apoptosis Is Attenuated by Bcl-2 but Restored by the Small Molecule Bcl-2 Inhibitor, HA 14-1, in Human Leukemia U937 Cells

Cheng-Yun Jin, Cheol Park, Jun-Hyuk Lee, Kyung Tae Chung, Taeg Kyu Kwon, Gi-Young Kim, Byung Tae Choi, Yung Hyun Choi

Toxicol In Vitro. 2009 Mar;23(2):259-65.

PMID: 19124070

1

sHA 14-1, a Stable and ROS-free Antagonist Against Anti-Apoptotic Bcl-2 Proteins, Bypasses Drug Resistances and Synergizes Cancer Therapies in Human Leukemia Cell

Defeng Tian, Sonia G Das, Jignesh M Doshi, Jun Peng, Jialing Lin, Chengguo Xing

Cancer Lett. 2008 Feb 8;259(2):198-208.

PMID: 18037229

1

Structure-activity Relationship Studies of Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (HA 14-1), an Antagonist for Antiapoptotic Bcl-2 Proteins to Overcome Drug Resistance in Cancer

Jignesh M Doshi, Defeng Tian, Chengguo Xing

J Med Chem. 2006 Dec 28;49(26):7731-9.

PMID: 17181155

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