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Histone Acetyltransferase p300 Inhibitor, C646

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For Research Use Only | Not For Clinical Use
CATAP328968361-B
CAS328968-36-1
Structure
Molecular Weight445.42
DescriptionHistone Acetyltransferase p300 Inhibitor, C646, CAS 328968-36-1, is a cell-permeable, reversible inhibitor of p300/CBP HAT (Ki = 400 nM). Competes with acetyl-CoA for the p300 Lys-CoA binding pocket.
SolubilityDMSO: 50 mg/mL
Assay≥99% (sum of isomers, HPLC)
Colorbrick red
Formsolid; protect from light
Size10MG
Storage Conditions-20C
1

A Histone Acetyltransferase p300 Inhibitor C646 Induces Cell Cycle Arrest and Apoptosis Selectively in AML1-ETO-positive AML Cells

Xiao-ning Gao, Ji Lin, Qiao-yang Ning, Li Gao, Yu-shi Yao, Ji-hao Zhou, Yong-hui Li, Li-li Wang, Li Yu

PLoS One. 2013;8(2):e55481.

PMID: 23390536

1

CBP/p300 Inhibitor C646 Prevents High Glucose Exposure Induced Neuroepithelial Cell Proliferation

Baoling Bai, Qin Zhang, Chunlei Wan, Dan Li, Ting Zhang, Huili Li

Birth Defects Res. 2018 Aug 15;110(14):1118-1128.

PMID: 30114346

1

p300 Mediates Muscle Wasting in Lewis Lung Carcinoma

Thomas K Sin, James Z Zhu, Guohua Zhang, Yi-Ping Li

Cancer Res. 2019 Apr 1;79(7):1331-1342.

PMID: 30705122

1

Selective p300 Inhibitor C646 Inhibited HPV E6-E7 Genes, Altered Glucose Metabolism and Induced Apoptosis in Cervical Cancer Cells

Hongpeng He, Yongwei Lai, Yunpeng Hao, Yupeng Liu, Zijiang Zhang, Xiang Liu, Chenhong Guo, Mengmeng Zhang, Hao Zhou, Nan Wang, Xue-Gang Luo, Lihong Huo, Wenjian Ma, Tong-Cun Zhang

Eur J Pharmacol. 2017 Oct 5;812:206-215.

PMID: 28619596

1

The Histone Acetyltransferase p300 Inhibitor C646 Reduces Pro-Inflammatory Gene Expression and Inhibits Histone Deacetylases

Thea van den Bosch, Alexander Boichenko, Niek G J Leus, Maria E Ourailidou, Hannah Wapenaar, Dante Rotili, Antonello Mai, Axel Imhof, Rainer Bischoff, Hidde J Haisma, Frank J Dekker

Biochem Pharmacol. 2016 Feb 15;102:130-140.

PMID: 26718586

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