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HMR-1556

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For Research Use Only | Not For Clinical Use
CATAP223749460
CAS223749-46-0
Structure
MDL NumberMFCD12756323
Molecular Weight411.44
Description≥98% (HPLC)
SolubilityDMSO: 2 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

Blockade of IKs by HMR 1556 Increases the Reverse Rate-Dependence of Refractoriness Prolongation by Dofetilide in Isolated Rabbit Ventricles

Petsy Pui-Sze So, Xu-Dong Hu, Peter H Backx, José Luis Puglisi, Paul Dorian

Br J Pharmacol. 2006 Jun;148(3):255-63.

PMID: 16565733

1

Effects of the Chromanol HMR 1556 on Potassium Currents in Atrial Myocytes

Ralph F Bosch, Alexander C Schneck, Saskia Csillag, Bernd Eigenberger, Uwe Gerlach, Joachim Brendel, Hans J Lang, Christian Mewis, Heinz Gögelein, Ludger Seipel, Volker Kühlkamp

Naunyn Schmiedebergs Arch Pharmacol. 2003 Mar;367(3):281-8.

PMID: 12644901

1

HMR 1556, a Potent and Selective Blocker of Slowly Activating Delayed Rectifier Potassium Current

George P Thomas, Uwe Gerlach, Charles Antzelevitch

J Cardiovasc Pharmacol. 2003 Jan;41(1):140-7.

PMID: 12500032

1

Inhibition of IKs Channels by HMR 1556

H Gögelein, A Brüggemann, U Gerlach, J Brendel, A E Busch

Naunyn Schmiedebergs Arch Pharmacol. 2000 Dec;362(6):480-8.

PMID: 11138839

1

The New Selective I(Ks)-blocking Agent HMR 1556 Restores Sinus Rhythm and Prevents Heart Failure in Pigs With Persistent Atrial Fibrillation

Alexander Bauer, Martin Koch, Patricia Kraft, Ruediger Becker, Kamila Kelemen, Frederik Voss, Julia C Senges, Uwe Gerlach, Hugo A Katus, Wolfgang Schoels

Basic Res Cardiol. 2005 May;100(3):270-8.

PMID: 15795798

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