α-Humulene

INQUIRY Add to cart

For Research Use Only | Not For Clinical Use

CAT	AP6753986
CAS	6753-98-6
Structure
MDL Number	MFCD00042689
Molecular Weight	204.35
EC Number	229-816-7
InChI Key	FAMPSKZZVDUYOS-HRGUGZIWSA-N
REAXYS Number	3240075

Characterization of α-humulene Synthases Responsible for the Production of Sesquiterpenes Induced by Methyl Jasmonate in Aquilaria Cell Culture

Yukie Kumeta, Michiho Ito

J Nat Med. 2016 Jul;70(3):452-9.

PMID: 27180085

CO 2 to Terpenes: Autotrophic and Electroautotrophic α-Humulene Production with Cupriavidus necator

Thomas Krieg, Anne Sydow, Sonja Faust, Ina Huth, Dirk Holtmann

Angew Chem Int Ed Engl. 2018 Feb 12;57(7):1879-1882.

PMID: 29232490

Sesquiterpenes α-humulene and β-caryophyllene Oxide Enhance the Efficacy of 5-fluorouracil and Oxaliplatin in Colon Cancer Cells

Martin Ambrož, Markéta Šmatová, Michaela Šadibolová, Eva Pospíšilová, Pavlína Hadravská, Michaela Kašparová, Veronika Hanušová Skarková, Věra Králová, Lenka Skálová

Acta Pharm. 2019 Mar 1;69(1):121-128.

PMID: 31259712

The Gas-Phase Ozonolysis of α-humulene

M Beck, R Winterhalter, F Herrmann, G K Moortgat

Phys Chem Chem Phys. 2011 Jun 21;13(23):10970-1001.

PMID: 21461420

α-Humulene Inhibits Hepatocellular Carcinoma Cell Proliferation and Induces Apoptosis Through the Inhibition of Akt Signaling

Hao Chen, Jingquan Yuan, Ji Hao, Yanzhang Wen, Yibing Lv, Lu Chen, Xinzhou Yang

Food Chem Toxicol. 2019 Dec;134:110830.

PMID: 31562948

* Products or Services Interested: α-Humulene (6753-98-6)
* Your question
* Name
* Email
Verification Code

CAT	Size	Form	Description	Price
AP6753986-1	250MG	neat; gas chromatography (GC): suitable	analytical standard	Inquiry
AP6753986-2	1ML, 5ML		≥96.0% (GC)	Inquiry

Case Study

α-Humulene (HML) Inhibits Hepatocellular Carcinoma (HCC) Cell Proliferation

Chen, Hao, et al. Food and Chemical Toxicology 134 (2019): 110830.

HHepatocellular carcinoma (HCC) is a common malignant tumor and a leading cause of cancer-related death. α-Humulene (HML) is a natural monocyclic terpene with three E-type double bonds, isolated from Eupatorium odoratum L. Recently, HML has been found to possess significant anti-HCC activity both in vitro and in vivo.
Studies have shown that HML exhibits cytotoxicity against HCC cells and induces mitochondrial apoptosis in these cells, promoting caspase-3 activation and PARP cleavage. HCC cells exhibit abnormal Akt signaling to resist apoptosis. Mechanistically, HML was found to inhibit Akt activation, subsequently reducing the phosphorylation of GSK-3 and Bad, thereby promoting apoptosis induction. HML also suppressed cell proliferation in HCC tumor xenografts and enhanced apoptosis, further highlighting its in vivo activity. Despite minimal cytotoxicity to normal liver cells, weight loss was observed in mice treated with HML.
In summary, these data provide important and novel insights into the anti-HCC effects of HML by inhibiting Akt, reducing HCC cell proliferation, and enhancing the induction of apoptosis in HCC cells both in vitro and in vivo.

Send Us a Request

What is your specific need? We will do everything we can to meet your expectations.

Online Inquiry