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Hypothemycin

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For Research Use Only | Not For Clinical Use
CATAP76958673
CAS76958-67-3
Structure
MDL NumberMFCD08457932
Molecular Weight378.37
InChI KeySSNQAUBBJYCSMY-KNTMUCJRSA-N
Descriptionfrom Hypomyces trichothecoides, ≥98% (HPLC)
SolubilityDMSO: soluble; acetone: soluble; deionized water: insoluble
Assay≥98% (HPLC)
Size250UG, 1MG
Storage Conditions−20°C
1

Concurrent Inhibition of Kit- And FcepsilonRI-mediated Signaling: Coordinated Suppression of Mast Cell Activation

Bettina M Jensen, Michael A Beaven, Shoko Iwaki, Dean D Metcalfe, Alasdair M Gilfillan

J Pharmacol Exp Ther. 2008 Jan;324(1):128-38.

PMID: 17925481

1

Genes for the Biosynthesis of the Fungal Polyketides Hypothemycin From Hypomyces Subiculosus and Radicicol From Pochonia Chlamydosporia

Christopher D Reeves, Zhihao Hu, Ralph Reid, James T Kealey

Appl Environ Microbiol. 2008 Aug;74(16):5121-9.

PMID: 18567690

1

Hypothemycin Inhibits Tumor Necrosis factor-α Production by Tristetraprolin-Dependent Down-Regulation of mRNA Stability in Lipopolysaccharide-Stimulated Macrophages

Ki Hwan Park, Yeo Dae Yoon, Moo Rim Kang, Jieun Yun, Soo Jin Oh, Chang Woo Lee, Myeong Youl Lee, Sang-Bae Han, Youngsoo Kim, Jong Soon Kang

Int Immunopharmacol. 2015 Dec;29(2):863-868.

PMID: 26371861

1

Suppression of Oncogenic Transformation by Hypothemycin Associated With Accelerated Cyclin D1 Degradation Through Ubiquitin-Proteasome Pathway

H Sonoda, K Omi, K Hojo, K Nishida, S Omura, K Sugita

Life Sci. 1999;65(4):381-94.

PMID: 10421424

1

The Resorcylic Acid Lactone Hypothemycin Selectively Inhibits the Mitogen-Activated Protein Kinase Kinase-Extracellular Signal-Regulated Kinase Pathway in Cells

Hidesuke Fukazawa, Yoshimi Ikeda, Mari Fukuyama, Takeshi Suzuki, Hiroshi Hori, Toru Okuda, Yoshimasa Uehara

Biol Pharm Bull. 2010;33(2):168-73.

PMID: 20118535

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