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I-BET762

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For Research Use Only | Not For Clinical Use
CATAP1260907172
CAS1260907-17-2
Structure
MDL NumberMFCD22417091
Molecular Weight423.90
InChI KeyAAAQFGUYHFJNHI-SFHVURJKSA-N
Description≥98% (HPLC)
SolubilityDMSO: 10 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

Discovery of Epigenetic Regulator I-BET762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the BET Bromodomains

Olivier Mirguet, Romain Gosmini, Jérôme Toum, Catherine A Clément, Mélanie Barnathan, Jean-Marie Brusq, Jacqueline E Mordaunt, Richard M Grimes, Miriam Crowe, Olivier Pineau, Myriam Ajakane, Alain Daugan, etc.

J Med Chem. 2013 Oct 10;56(19):7501-15.

PMID: 24015967

1

Potent Antimyeloma Activity of the Novel Bromodomain Inhibitors I-BET151 and I-BET762

Aristeidis Chaidos, Valentina Caputo, Katerina Gouvedenou, Binbin Liu, Ilaria Marigo, Mohammed Suhail Chaudhry, Antonia Rotolo, David F Tough, Nicholas N Smithers, Anna K Bassil, Trevor D Chapman, Nicola R Harker, etc.

Blood. 2014 Jan 30;123(5):697-705.

PMID: 24335499

1

The BET Inhibitor I-BET762 Inhibits Pancreatic Ductal Adenocarcinoma Cell Proliferation and Enhances the Therapeutic Effect of Gemcitabine

Fang Xie, Mei Huang, Xiansheng Lin, Chenhai Liu, Zhen Liu, Futao Meng, Chao Wang, Qiang Huang

Sci Rep. 2018 May 25;8(1):8102.

PMID: 29802402

1

The Making of I-BET762, a BET Bromodomain Inhibitor Now in Clinical Development

Yujun Zhao, Chao-Yie Yang, Shaomeng Wang

J Med Chem. 2013 Oct 10;56(19):7498-500.

PMID: 24107192

1

Therapeutic Targeting of BET Bromodomain Proteins in Castration-Resistant Prostate Cancer

Irfan A Asangani, Vijaya L Dommeti, Xiaoju Wang, Rohit Malik, Marcin Cieslik, Rendong Yang, June Escara-Wilke, Kari Wilder-Romans, Sudheer Dhanireddy, Carl Engelke, Mathew K Iyer, Xiaojun Jing, Yi-Mi Wu, etc.

Nature. 2014 Jun 12;510(7504):278-82.

PMID: 24759320

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