CAS 1714146-59-4 I-BRD9 - Analytical Products / Alfa Chemistry

CAT	AP1714146594
CAS	1714146-59-4
MDL Number	MFCD28952791
Molecular Weight	497.55
InChI Key	WRUWGLUCNBMGPS-UHFFFAOYSA-N

Description	≥98% (HPLC)
Solubility	DMSO: 20 mg/mL, clear
Assay	≥98% (HPLC)
Color	white to beige
Form	powder
Size	5MG, 25MG
Storage Conditions	−20°C

1

BRD9 Inhibition, Alone or in Combination With Cytostatic Compounds as a Therapeutic Approach in Rhabdoid Tumors

Katja F Krämer, Natalia Moreno, Michael C Frühwald, Kornelius Kerl

Int J Mol Sci. 2017 Jul 16;18(7):1537.

PMID: 28714904

1

Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition

Natalie H Theodoulou, Paul Bamborough, Andrew J Bannister, Isabelle Becher, Rino A Bit, Ka Hing Che, Chun-wa Chung, Antje Dittmann, Gerard Drewes, David H Drewry, Laurie Gordon, Paola Grandi, Melanie Leveridge, etc.

J Med Chem. 2016 Feb 25;59(4):1425-39.

PMID: 25856009

1

Insight Into Selective Mechanism of Class of I-BRD9 Inhibitors Toward BRD9 Based on Molecular Dynamics Simulations

Jing Su, Xinguo Liu, Shaolong Zhang, Fangfang Yan, Qinggang Zhang, Jianzhong Chen

Chem Biol Drug Des. 2019 Feb;93(2):163-176.

PMID: 30225973

1

The Bromodomain Containing Protein BRD-9 Orchestrates RAD51-RAD54 Complex Formation and Regulates Homologous Recombination-Mediated Repair

Qin Zhou, Jinzhou Huang, Chao Zhang, Fei Zhao, Wootae Kim, Xinyi Tu, Yong Zhang, Somaira Nowsheen, Qian Zhu, Min Deng, Yuping Chen, Bo Qin, Kuntian Luo, Baohua Liu, Zhenkun Lou, Robert W Mutter, Jian Yuan

Nat Commun. 2020 May 26;11(1):2639.

PMID: 32457312

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