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ICA-069673

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For Research Use Only | Not For Clinical Use
CATAP582323168
CAS582323-16-8
MDL NumberMFCD20926351
Molecular Weight269.63
InChI KeyIIBSHMFXVWTQSJ-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: 20 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditionsroom temp
1

Differential Activation of Vascular Smooth Muscle Kv7.4, Kv7.5, and Kv7.4/7.5 Channels by ML213 and ICA-069673

Lyubov I Brueggemann, Jennifer M Haick, Leanne L Cribbs, Kenneth L Byron

Mol Pharmacol. 2014 Sep;86(3):330-41.

PMID: 24944189

1

Four Drug-Sensitive Subunits Are Required for Maximal Effect of a Voltage Sensor-Targeted KCNQ Opener

Alice W Wang, Michael C Yau, Caroline K Wang, Nazlee Sharmin, Runying Y Yang, Stephan A Pless, Harley T Kurata

J Gen Physiol. 2018 Oct 1;150(10):1432-1443.

PMID: 30166313

1

One Drug-Sensitive Subunit Is Sufficient for a Near-Maximal Retigabine Effect in KCNQ Channels

Michael C Yau, Robin Y Kim, Caroline K Wang, Jingru Li, Tarek Ammar, Runying Y Yang, Stephan A Pless, Harley T Kurata

J Gen Physiol. 2018 Oct 1;150(10):1421-1431.

PMID: 30166314

1

Pore- And Voltage Sensor-Targeted KCNQ Openers Have Distinct State-Dependent Actions

Caroline K Wang, Shawn M Lamothe, Alice W Wang, Runying Y Yang, Harley T Kurata

J Gen Physiol. 2018 Dec 3;150(12):1722-1734.

PMID: 30373787

1

The Novel KV7.2/KV7.3 Channel Opener ICA-069673 Reveals Subtype-Specific Functional Roles in Guinea Pig Detrusor Smooth Muscle Excitability and Contractility

Aaron Provence, John Malysz, Georgi V Petkov

J Pharmacol Exp Ther. 2015 Sep;354(3):290-301.

PMID: 26087697

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