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ICRF-193

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For Research Use Only | Not For Clinical Use
CATAP21416886
CAS21416-88-6
Structure
MDL NumberMFCD01702964
Molecular Weight282.30
InChI KeyOBYGAPWKTPDTAS-OCAPTIKFSA-N
Descriptionapoptosis inducer, arabinosidase substrate
SolubilityDMSO: 4 mg/mL
Assay≥95%
Size1MG, 5MG
Storage Conditions−20°C
1

ICRF-193 Modifies Etoposide-Induced Apoptosis in Thymocytes

C Tanimoto, S Hirakawa, H Kawasaki, N Hayakawa, Z Ota

Acta Med Okayama. 1995 Dec;49(6):281-6.

PMID: 8770236

1

ICRF-193, a Catalytic Inhibitor of DNA Topoisomerase II, Inhibits Re-Entry Into the Cell Division Cycle From Quiescent State in Mammalian Cells

Muktadir S Hossain, Nobuyoshi Akimitsu, Tohru Takaki, Hiroshi Hirai, Kazuhisa Sekimizu

Genes Cells. 2002 Mar;7(3):285-94.

PMID: 11918672

1

ICRF-193, an Anticancer Topoisomerase II Inhibitor, Induces Arched Telophase Spindles That Snap, Leading to a Ploidy Increase in Fission Yeast

Norihiko Nakazawa, Rajesh Mehrotra, Orie Arakawa, Mitsuhiro Yanagida

Genes Cells. 2016 Sep;21(9):978-93.

PMID: 27458047

1

The Topoisomerase II Catalytic Inhibitor ICRF-193 Preferentially Targets Telomeres That Are Capped by TRF2

Lianxiang Chen, Xiaowei Zhu, Yaru Zou, Jun Xing, Eric Gilson, Yiming Lu, Jing Ye

Am J Physiol Cell Physiol. 2015 Mar 1;308(5):C372-7.

PMID: 25518961

1

Topoisomerase II Poisoning by ICRF-193

K C Huang, H Gao, E F Yamasaki, D R Grabowski, S Liu, L L Shen, K K Chan, R Ganapathi, R M Snapka

J Biol Chem. 2001 Nov 30;276(48):44488-94.

PMID: 11577077

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