CAS 868612-83-3 IN-1130 - Analytical Products / Alfa Chemistry

CAT	AP868612833
CAS	868612-83-3
Molecular Weight	420.47

Description	≥98% (HPLC)
Solubility	DMSO: 10 mg/mL, clear
Assay	≥98% (HPLC)
Color	white to beige
Form	powder
Size	5MG, 25MG
Storage Conditions	2-8°C

1

An Novel Inhibitor of TGF-β Type I Receptor, IN-1130, Blocks Breast Cancer Lung Metastasis Through Inhibition of Epithelial-Mesenchymal Transition

Chul-Yong Park, Kyung Nan Min, Jee-Yeon Son, So-Yeon Park, Jeong-Seok Nam, Dae-Kee Kim, Yhun Yhong Sheen

Cancer Lett. 2014 Aug 28;351(1):72-80.

PMID: 24887560

1

Effect of IN-1130, a Small Molecule Inhibitor of Transforming Growth Factor-Beta Type I receptor/activin Receptor-Like kinase-5, on Prostate Cancer Cells

Geun Taek Lee, Jun Hyuk Hong, Thomas J Mueller, John A Watson, Cheol Kwak, Youn Young Sheen, Dae-Kee Kim, Seong Jin Kim, Isaac Yi Kim

J Urol. 2008 Dec;180(6):2660-7.

PMID: 18951571

1

Identification of Human Cytochrome P450 Enzymes Involved in the Metabolism of IN-1130, a Novel Activin Receptor-Like kinase-5 (ALK5) Inhibitor

Y W Kim, Y K Kim, D-K Kim, Y Y Sheen

Xenobiotica. 2008 May;38(5):451-64.

PMID: 18421620

1

IN-1130, a Novel Transforming Growth Factor-Beta Type I Receptor Kinase (Activin Receptor-Like Kinase 5) Inhibitor, Promotes Regression of Fibrotic Plaque and Corrects Penile Curvature in a Rat Model of Peyronie's Disease

Ji-Kan Ryu, Shuguang Piao, Hwa-Yean Shin, Min Ji Choi, Lu Wei Zhang, Hai-Rong Jin, Woo Jean Kim, Jee-Young Han, Soon Sun Hong, Seok Hee Park, Sang-Jin Lee, In-Hoo Kim, Chung Ryul Lee, Dae-Kee Kim, Mizuko Mamura, etc.

J Sex Med. 2009 May;6(5):1284-96.

PMID: 19473283

1

IN-1130, a Novel Transforming Growth Factor-Beta Type I Receptor Kinase (ALK5) Inhibitor, Suppresses Renal Fibrosis in Obstructive Nephropathy

J-A Moon, H-T Kim, I-S Cho, Y Y Sheen, D-K Kim

Kidney Int. 2006 Oct;70(7):1234-43.

PMID: 16929250

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