InSolution SB 203580 - Analytical Products / Alfa Chemistry

CAT	IAR42415514
Molecular Weight	377.43

Description	InSolution SB 203580, CAS 152121-47-6, is a 1 mg/ml solution of SB 203580 in DMSO. A cell-permeable, selective, reversible inhibitor of p38 MAP kinase (IC₅₀ = 34 nM in vitro, 600 nM in cells).
Assay	≥98% (HPLC)
Form	liquid; protect from light
Size	1ML
Storage Conditions	-20C

1

A Role for the p38 Mitogen-Activated Protein kinase/Hsp 27 Pathway in Cholecystokinin-Induced Changes in the Actin Cytoskeleton in Rat Pancreatic Acini

C Schäfer, S E Ross, M J Bragado, G E Groblewski, S A Ernst, J A Williams

J Biol Chem. 1998 Sep 11;273(37):24173-80.

PMID: 9727040

1

Effects of sphingosine-1-phosphate on Pacemaker Activity of Interstitial Cells of Cajal From Mouse Small Intestine

Young Dae Kim, Kyoung Taek Han, Jun Lee, Chan Guk Park, Man Yoo Kim, Pawan Kumar Shahi, Dong Chuan Zuo, Seok Choi, Jae Yeoul Jun

Mol Cells. 2013 Jan;35(1):79-86.

PMID: 23307289

1

Melatonin Prevents Secondary Intra-Abdominal Hypertension in Rats Possibly Through Inhibition of the p38 MAPK Pathway

Mingtao Chang, Yang Li, Dong Liu, Lianyang Zhang, Hongguang Zhang, Hao Tang, Huayu Zhang

Free Radic Biol Med. 2016 Aug;97:192-203.

PMID: 27264238

1

Preclinical Pharmacokinetics of SB-203580, a Potent Inhibitor of p38 Mitogen-Activated Protein Kinase

K W Ward, J W Prokscht, L M Azzaranot, J A Mumawa, T J Roethke, G J Stelman, M J Walsh, K S Zeigler, J E McSurdy-Freed, J R Kehlert, J Chokshi, M A Levy, B R Smith

Xenobiotica. 2001 Nov;31(11):783-97.

PMID: 11765141

1

TRPV1 Activation Is Required for Hypertonicity-Stimulated Inflammatory Cytokine Release in Human Corneal Epithelial Cells

Zan Pan, Zheng Wang, Hua Yang, Fan Zhang, Peter S Reinach

Invest Ophthalmol Vis Sci. 2011 Jan 21;52(1):485-93.

PMID: 20739465

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