InSolution Y-27632 - Analytical Products / Alfa Chemistry

CAT	IAR42415741
Molecular Weight	247.34

Description	Y-27632A, CAS 146986-50-7, is a cell-permeable, reversible, inhibitor of Rho kinases (Ki = 140 nM for p160ROCK). Enhances survival & cloning efficiency of ESC without affecting their pluripotency.
Assay	≥95% (HPLC)
Form	liquid; protect from light
Size	500μG
Storage Conditions	-20C

1

A Selective Inhibitor of the Rho Kinase Pathway, Y-27632, and Its Influence on Wound Healing in the Corneal Stroma

Mayumi Yamamoto, Andrew J Quantock, Robert D Young, Naoki Okumura, Morio Ueno, Yuji Sakamoto, Shigeru Kinoshita, Noriko Koizumi

Mol Vis. 2012;18:1727-39.

PMID: 22815626

1

Effects of HA-1077 and Y-27632, Two Rho-Kinase Inhibitors, in the Human Umbilical Artery

Mustafa Ark, Elif Ozveren, Gürkan Yazici, Belma Korkmaz, Kansu Büyükafsar, Onur Arikan, Havva Kubat, Emel Songu-Mize

Cell Biochem Biophys. 2004;41(3):331-42.

PMID: 15509884

1

Protective Effects of Dexpanthenol and y-27632 on Stricture Formation in a Rat Model of Caustic Esophageal Injury

Haluk Ceylan, Sefa Yapici, Ediz Tutar, Nurdan Ozlu Ceylan, Mehmet Tarakçıoğlu, A Tuncay Demiryurek

J Surg Res. 2011 Dec;171(2):517-23.

PMID: 20691993

1

ROCK Inhibitor Y-27632 Inhibits the Growth, Migration, and Invasion of Tca8113 and CAL-27 Cells in Tongue Squamous Cell Carcinoma

Zhi-Ming Wang, Dong-Sheng Yang, Jie Liu, Hong-Bo Liu, Ming Ye, Yu-Fei Zhang

Tumour Biol. 2016 Mar;37(3):3757-64.

PMID: 26468018

1

Y-27632 Preserves Epidermal Integrity in a Human Skin Organ-Culture (hSOC) System by Regulating AKT and ERK Signaling Pathways

Xuan Zhang, Jing Qin, Zhiwei Xie, Chang Liu, Yiqun Su, Zhihong Chen, Qian Zhou, Chuan Ma, Guanyi Liu, Ralf Paus, Jing Guo, Xunwei Wu

J Dermatol Sci. 2019 Nov;96(2):99-109.

PMID: 31718896