CAS 13478-10-9 Iron(II) chloride tetrahydrate - Analytical Products / Alfa Chemistry

CAT	AP13478109
CAS	13478-10-9
Structure
MDL Number	MFCD00149709
Molecular Weight	198.81
EC Number	231-843-4
InChI Key	WSSMOXHYUFMBLS-UHFFFAOYSA-L

Linear Formula

FeCl2 · 4H2O

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J Vis Exp. 2016 May 26;(111):52951.

PMID: 27285589

Orthogonal Projection Approach and Continuous Wavelet Transform-Feed Forward Neural Networks for Simultaneous Spectrophotometric Determination of Some Heavy Metals in Diet Samples

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Understanding the Role of Iron Chlorides in the De Novo Synthesis of Polychlorinated dibenzo-p-dioxins/dibenzofurans

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PMID: 15074679

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CAT	Size	Form	Description	Price
AP13478109-1	50G, 250G, 1KG		puriss. p.a., ≥99.0% (RT)	Inquiry
AP13478109-2	5G, 25G	crystals and lumps	99.99% trace metals basis	Inquiry

Case Study

FeCl₂·4H₂O Used for the Synthesis of Magnetic Fe₃O₄ Nanoparticles for Green Nanocatalyst Preparation in 2-Amino-4H-Chromene Synthesis

Poursattar Marjani, Ahmad, Fatemeh Asadzadeh, and Aria Danandeh Asl. Scientific Reports 12.1 (2022): 22173.

Ferrous chloride tetrahydrate (FeCl₂·4H₂O) serves as a critical precursor in the co-precipitation synthesis of Fe₃O₄ magnetic nanoparticles (MNPs), which are subsequently employed in developing a recyclable nanocatalyst for green organic synthesis. In a 1:2 molar ratio with FeCl₃·6H₂O, FeCl₂·4H₂O was dissolved in deionized water and reacted under alkaline conditions with ammonium hydroxide at 80 °C, yielding magnetically responsive Fe₃O₄ nanoparticles. These were further functionalized with 3-chloropropyltrimethoxysilane, glycerol, and CuSO₄·5H₂O to fabricate the Fe₃O₄@Glycerol-Cu nanocatalyst.
The resulting composite catalyst demonstrated excellent activity in the multicomponent synthesis of 2-amino-4H-chromenes from arylglyoxals, malononitrile, and cyclic 1,3-dicarbonyl compounds under mild conditions (room temperature, EtOH). Notably, the reaction proceeded efficiently within 15-20 minutes and allowed easy magnetic recovery and reuse of the catalyst, aligning with green chemistry principles.
FeCl₂·4H₂O plays an essential role in the initial magnetite formation, influencing nanoparticle size, crystallinity, and magnetic properties, which are critical for catalyst performance. This study highlights the utility of FeCl₂·4H₂O in nanomaterial synthesis and its downstream applications in environmentally friendly, cost-effective organic reactions.

FeCl₂·4H₂O Used for the Synthesis of Iron(II) Complexes Featuring Ligand Backbone Esterification

Zhang, Qian, et al. Inorganic Chemistry 64.10 (2025): 4934-4946.

Ferrous chloride tetrahydrate (FeCl₂·4H₂O) plays a pivotal role in the synthesis of a new class of iron(II) coordination complexes via a unique ligand-modification route involving in situ esterification. Under solvothermal conditions in ethanol, FeCl₂·4H₂O reacts with a trifluoromethyl-containing ligand, 3-(pyridin-2-yl)-1-(trifluoromethyl)imidazo[1,5-a]pyridine (PIP-CF₃), to yield complexes such as [Fe(PIP-COOEt)₂Cl₂], [Fe₂(PIP-COOEt)₂Cl₄], and [Fe(PIP-COOEt)Cl₂]. Remarkably, the reaction not only coordinates Fe(II) with the ligand but simultaneously transforms the -CF₃ group into an ester moiety (-COOR), where ethanol serves both as solvent and reactant.
The protocol demonstrates broad alcohol compatibility, enabling the incorporation of various alkyl esters (n-propyl, isopropyl, etc.) into the ligand backbone. This strategic use of FeCl₂·4H₂O supports the formation of mononuclear and dinuclear iron complexes with distinct coordination geometries, all characterized by X-ray crystallography.
FeCl₂·4H₂O is crucial not only as the Fe(II) source but also as a facilitator of ligand transformation under mild, alcohol-assisted conditions. This dual-function system underscores the value of FeCl₂·4H₂O in designing multifunctional coordination compounds and contributes to novel methodologies in metal-ligand cooperative chemistry.

FeCl₂·4H₂O Used for the Synthesis of Air-Responsive Fe(II) Cluster Crystals via Solvothermal Assembly

Zhang, Ming, et al. Chemical science 8.8 (2017): 5356-5361.

Ferrous chloride tetrahydrate (FeCl₂·4H₂O) is a key precursor in the solvothermal synthesis of a rare, air-sensitive Fe(II) cluster: [FeII₄(mbm)₄Cl₄(MeOH)₄], where Hmbm is 2-(methoxycarbonyl)benzimidazole. Under autoclave heating at 140 °C in methanol with triethylamine, FeCl₂·4H₂O facilitates the formation of light yellow rhombic crystals of the tetranuclear Fe(II) complex. Remarkably, these non-porous crystals undergo a gas-solid phase transformation upon prolonged exposure to air, yielding a black Fe(III) hydroxide analogue: [FeIII₄(mbm)₄Cl₄(OH)₄]·2H₂O
This transformation includes ligand exchange (MeOH to OH⁻), oxidation of Fe(II) to Fe(III), stereochemical reconfiguration, and crystal hydration-all occurring without disruption of the original lattice symmetry or space group. Notably, this Fe(III) phase cannot be synthesized directly from FeCl₃·6H₂O under the same conditions, as methanol reduces Fe(III) back to Fe(II).
FeCl₂·4H₂O thus enables the synthesis of an Fe(II) framework that exhibits an exceptional solid-state redox behavior and stability under structural strain. This work highlights FeCl₂·4H₂O's crucial role in engineering redox-responsive crystalline materials and contributes significantly to the understanding of gas-solid transformations in coordination clusters.