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ISRIB

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For Research Use Only | Not For Clinical Use
CATIAR4243666
Molecular Weight451.34
InChI KeyHJGMCDHQPXTGAV-IYARVYRRSA-N
Description≥98% (HPLC)
SolubilityDMSO: 1 mg/mL, clear (warmed)
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

Binding of ISRIB Reveals a Regulatory Site in the Nucleotide Exchange Factor eIF2B

Alisa F Zyryanova, Félix Weis, Alexandre Faille, Akeel Abo Alard, Ana Crespillo-Casado, Yusuke Sekine, Heather P Harding, Felicity Allen, Leopold Parts, Christophe Fromont, Peter M Fischer, Alan J Warren, etc.

Science. 2018 Mar 30;359(6383):1533-1536.

PMID: 29599245

1

Integrated Stress Response Is Critical for Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma

L R Palam, J Gore, K E Craven, J L Wilson, M Korc

Cell Death Dis. 2015 Oct 15;6(10):e1913.

PMID: 26469962

1

Pharmacological Brake-Release of mRNA Translation Enhances Cognitive Memory

Carmela Sidrauski, Diego Acosta-Alvear, Arkady Khoutorsky, Punitha Vedantham, Brian R Hearn, Han Li, Karine Gamache, Ciara M Gallagher, Kenny K-H Ang, Chris Wilson, Voytek Okreglak, Avi Ashkenazi, Byron Hann, etc.

Elife. 2013 May 28;2:e00498.

PMID: 23741617

1

Pharmacological Dimerization and Activation of the Exchange Factor eIF2B Antagonizes the Integrated Stress Response

Carmela Sidrauski, Jordan C Tsai, Martin Kampmann, Brian R Hearn, Punitha Vedantham, Priyadarshini Jaishankar, Masaaki Sokabe, Aaron S Mendez, Billy W Newton, Edward L Tang, Erik Verschueren, Jeffrey R Johnson, etc.

Elife. 2015 Apr 15;4:e07314.

PMID: 25875391

1

Structure of the Nucleotide Exchange Factor eIF2B Reveals Mechanism of Memory-Enhancing Molecule

Jordan C Tsai, Lakshmi E Miller-Vedam, Aditya A Anand, Priyadarshini Jaishankar, Henry C Nguyen, Adam R Renslo, Adam Frost, Peter Walter

Science. 2018 Mar 30;359(6383):eaaq0939.

PMID: 29599213

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