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Itaconic acid

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For Research Use Only | Not For Clinical Use
CATAP97654
CAS97-65-4
Structure
MDL NumberMFCD00004260
Molecular Weight130.10
EC Number202-599-6
InChI KeyLVHBHZANLOWSRM-UHFFFAOYSA-N
REAXYS Number1759501
Descriptionanalytical standard
Density1.573 g/mL at 25 °C (lit.)
Assay≥96.0% (GC)
Autoignition Temperature1472 °F; gas chromatography (GC): suitable
Formneat
Gradeanalytical standard
Impurity Content≤0.5% water
Linear FormulaHO2CCH2C(=CH2)CO2H
MP165-168 °C (lit.)
Size100MG
1

IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid

Jan Naujoks, Christoph Tabeling, Brian D Dill, Christine Hoffmann, Andrew S Brown, Mareike Kunze, Stefan Kempa, Andrea Peter, Hans-Joachim Mollenkopf, Anca Dorhoi, Olivia Kershaw, Achim D Gruber, Leif E Sander, etc.

PLoS Pathog. 2016 Feb 1;12(2):e1005408.

PMID: 26829557

1

Immune-responsive Gene 1 Protein Links Metabolism to Immunity by Catalyzing Itaconic Acid Production

Alessandro Michelucci, Thekla Cordes, Jenny Ghelfi, Arnaud Pailot, Norbert Reiling, Oliver Goldmann, Tina Binz, André Wegner, Aravind Tallam, Antonio Rausell, Manuel Buttini, Carole L Linster, Eva Medina, etc.

Proc Natl Acad Sci U S A. 2013 May 7;110(19):7820-5.

PMID: 23610393

1

Itaconic Acid Indicates Cellular but Not Systemic Immune System Activation

Johannes Meiser, Lisa Kraemer, Christian Jaeger, Henning Madry, Andreas Link, Philipp M Lepper, Karsten Hiller, Jochen G Schneider

Oncotarget. 2018 Aug 14;9(63):32098-32107.

PMID: 30181801

1

Itaconic Acid Mediates Crosstalk Between Macrophage Metabolism and Peritoneal Tumors

Jonathan M Weiss, Luke C Davies, Megan Karwan, Lilia Ileva, Michelle K Ozaki, Robert Ys Cheng, Lisa A Ridnour, Christina M Annunziata, David A Wink, Daniel W McVicar

J Clin Invest. 2018 Aug 31;128(9):3794-3805.

PMID: 29920191

1

Itaconic Acid Production in Microorganisms

Meilin Zhao, Xinyao Lu, Hong Zong, Jinyang Li, Bin Zhuge

Biotechnol Lett. 2018 Mar;40(3):455-464.

PMID: 29299715

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