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IWR-1

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For Research Use Only | Not For Clinical Use
CATIAR4243595
Molecular Weight409.44
InChI KeyZGSXEXBYLJIOGF-ALFLXDJESA-N
Description≥98% (HPLC)
SolubilityDMSO: 5 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Size5MG, 25MG
Storage Conditionsroom temp
1

Efflux Inhibition by IWR-1-endo Confers Sensitivity to Doxorubicin Effects in Osteosarcoma Cells

Carl T Gustafson, Tewodros Mamo, Avudaiappan Maran, Michael J Yaszemski

Biochem Pharmacol. 2018 Apr;150:141-149.

PMID: 29412166

1

Inhibition of Collagen Synthesis by IWR-1 in Normal and Keloid-Derived Skin Fibroblasts

Ming-Wei Zhou, Wei-Tian Yin, Ri-Hua Jiang, Jin-Hyup Lee, Chang-Deok Kim, Jeung-Hoon Lee, Ming Ji Zhu, Tae-Jin Yoon

Life Sci. 2017 Mar 15;173:86-93.

PMID: 27939785

1

IWR-1 Inhibits Collagen-Induced Platelet Activation and Protects Against Thrombogenesis

Wei Wang, Songqing Lai, ZiJin Xiao, Haiyue Yan, Yongxi Li, Ye Zhang, Yanqing Wu, Ling Wang

Hamostaseologie. 2019 Nov;39(4):392-397.

PMID: 30849780

1

IWR-1 Inhibits Epithelial-Mesenchymal Transition of Colorectal Cancer Cells Through Suppressing Wnt/β-catenin Signaling as Well as Survivin Expression

Sang Chul Lee, Ok-Hee Kim, Sang Kuon Lee, Say-June Kim

Oncotarget. 2015 Sep 29;6(29):27146-59.

PMID: 26450645

1

IWR-1, a Tankyrase Inhibitor, Attenuates Wnt/β-catenin Signaling in Cancer Stem-Like Cells and Inhibits in Vivo the Growth of a Subcutaneous Human Osteosarcoma Xenograft

Sara R Martins-Neves, Daniela I Paiva-Oliveira, Carlos Fontes-Ribeiro, Judith V M G Bovée, Anne-Marie Cleton-Jansen, Célia M F Gomes

Cancer Lett. 2018 Feb 1;414:1-15.

PMID: 29126913

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