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JK184

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For Research Use Only | Not For Clinical Use
CATAP315703527
CAS315703-52-7
Structure
Molecular Weight350.44
InChI KeyCBKFVRMNQUKWPX-UHFFFAOYSA-N
Description≥98% (HPLC), powder
SolubilityDMSO: ≥20 mg/mL
Assay≥98% (HPLC)
Coloroff-white to light brown
Formpowder
Size5MG, 25MG
Storage Conditionsroom temp
1

Biodegradable Polymeric Micelles Encapsulated JK184 Suppress Tumor Growth Through Inhibiting Hedgehog Signaling Pathway

Nannan Zhang, Shichang Liu, Ning Wang, Senyi Deng, Linjiang Song, Qinjie Wu, Lei Liu, Weijun Su, Yuquan Wei, Yongmei Xie, Changyang Gong

Nanoscale. 2015 Feb 14;7(6):2609-24.

PMID: 25581613

1

Combined Effects of EGFR and Hedgehog Signaling Blockade on Inhibition of Head and Neck Squamous Cell Carcinoma

Jun Liu, Yaliu Xie, Sisi Wu, Dan Lv, Xuemei Wei, Fei Chen, Zhenling Wang

Int J Clin Exp Pathol. 2017 Sep 1;10(9):9816-9828.

PMID: 31966869

1

Inhibition of JK184-Induced Cytoprotective Autophagy Potentiates JK184 Antitumor Effects in Breast Cancer

Xiaoya Xi, Tao He

J Oncol. 2020 Jun 2;2020:1657896.

PMID: 32565796

1

Pharmacological Targeting of GLI1 Inhibits Proliferation, Tumor Emboli Formation and in Vivo Tumor Growth of Inflammatory Breast Cancer Cells

Helen O Oladapo, Michael Tarpley, Scott J Sauer, Kezia A Addo, Shalonda M Ingram, Dillon Strepay, Ben K Ehe, Lhoucine Chdid, Michael Trinkler, Jose R Roques, David B Darr, Jodie M Fleming, Gayathri R Devi, etc.

Cancer Lett. 2017 Dec 28;411:136-149.

PMID: 28965853

1

The Imidazopyridine Derivative JK184 Reveals Dual Roles for Microtubules in Hedgehog Signaling

Tommaso Cupido, Paul G Rack, Ari J Firestone, Joel M Hyman, Kyuho Han, Surajit Sinha, Cory A Ocasio, James K Chen

Angew Chem Int Ed Engl. 2009;48(13):2321-4.

PMID: 19222062

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