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JNJ-63533054

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For Research Use Only | Not For Clinical Use
CATAP1802326664
CAS1802326-66-4
Molecular Weight316.78
Description≥98% (HPLC)
SolubilityDMSO: 20 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditionsroom temp
1

GPR139, an Orphan Receptor Highly Enriched in the Habenula and Septum, Is Activated by the Essential Amino Acids L-Tryptophan and L-Phenylalanine

Changlu Liu, Pascal Bonaventure, Grace Lee, Diane Nepomuceno, Chester Kuei, Jiejun Wu, Qingqin Li, Victory Joseph, Steven W Sutton, William Eckert, Xiang Yao, Lynn Yieh, Curt Dvorak, Nicholas Carruthers, etc.

Mol Pharmacol. 2015 Nov;88(5):911-25.

PMID: 26349500

1

In vivo Characterization of a Selective, Orally Available, and Brain Penetrant Small Molecule GPR139 Agonist

James R Shoblock, Natalie Welty, Ian Fraser, Ryan Wyatt, Brian Lord, Timothy Lovenberg, Changlu Liu, Pascal Bonaventure

Front Pharmacol. 2019 Mar 21;10:273.

PMID: 30949055

1

Putative Role of GPR139 on Sleep Modulation Using Pharmacological and Genetic Rodent Models

Lien Wang, Christine Dugovic, Sujin Yun, Allison White, Brian Lord, Curt Dvorak, Changlu Liu, Timothy Lovenberg, Pascal Bonaventure

Eur J Pharmacol. 2020 Jun 9;882:173256.

PMID: 32531213

1

Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139

Diane Nepomuceno, Chester Kuei, Curt Dvorak, Timothy Lovenberg, Changlu Liu, Pascal Bonaventure

Front Pharmacol. 2018 Mar 2;9:157.

PMID: 29599718

1

Systemic and Intra-Habenular Activation of the Orphan G Protein-Coupled Receptor GPR139 Decreases Compulsive-Like Alcohol Drinking and Hyperalgesia in Alcohol-Dependent Rats

Jenni Kononoff, Marsida Kallupi, Adam Kimbrough, Dana Conlisk, Giordano de Guglielmo, Olivier George

eNeuro. 2018 Jul 2;5(3):ENEURO.0153-18.2018.

PMID: 29971251

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