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JNJ7777120

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For Research Use Only | Not For Clinical Use
CATAP459168413
CAS459168-41-3
Structure
MDL NumberMFCD04343337
Molecular Weight277.75
InChI KeyHUQJRYMLJBBEDO-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: >20 mg/mL; H2O: insoluble
Assay≥98% (HPLC)
Colorwhite to off-white
Formsolid
Size5MG, 25MG
Storage Conditionsroom temp
1

Agonist-biased Signaling at the Histamine H4 Receptor: JNJ7777120 Recruits β-arrestin Without Activating G Proteins

Elizabeth M Rosethorne, Steven J Charlton

Mol Pharmacol. 2011 Apr;79(4):749-57.

PMID: 21134907

1

Effects of PARP-1 Deficiency and Histamine H 4 Receptor Inhibition in an Inflammatory Model of Lung Fibrosis in Mice

Mariaconcetta Durante, Silvia Sgambellone, Cecilia Lanzi, Patrizia Nardini, Alessandro Pini, Flavio Moroni, Emanuela Masini, Laura Lucarini

Front Pharmacol. 2019 May 16;10:525.

PMID: 31164820

1

JNJ7777120 Ameliorates Inflammatory and Oxidative Manifestations in a Murine Model of Contact Hypersensitivity via Modulation of TLR and Nrf2 Signaling

Ahmed F Mohamed, Mohammed F El-Yamany, Fatma A El-Batrawy, Mohamed T Abdel-Aziz

Inflammation. 2018 Mar;41(2):378-389.

PMID: 29127662

1

Protection of Radiation-Induced Damage to the Hematopoietic System, Small Intestine and Salivary Glands in Rats by JNJ7777120 Compound, a Histamine H4 Ligand

Diego J Martinel Lamas, Eliana Carabajal, Juan P Prestifilippo, Luis Rossi, Juan C Elverdin, Susana Merani, Rosa M Bergoc, Elena S Rivera, Vanina A Medina

PLoS One. 2013 Jul 26;8(7):e69106.

PMID: 23922686

1

The Effect of Selective Antagonist of H4 Receptor JNJ7777120 on Nasal Symptoms, Cough, Airway Reactivity and Inflammation in Guinea Pigs

E Kovacova-Hanuskova, S Gavliakova, T Buday, P Kosutova, D Mokra, A Urbanova-Fulmekova, J Mokry, J Plevkova

Respir Physiol Neurobiol. 2015 Sep 15;216:9-14.

PMID: 26003849

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