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JNK Inhibitor II - CAS 129-56-6

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For Research Use Only | Not For Clinical Use
CATAP129566
CAS129-56-6
Structure
Molecular Weight220.23
DescriptionJNK Inhibitor II. SP600125, CAS 129-56-6, is a potent, cell-permeable, selective, and ATP competitive inhibitor of c-Jun N-terminal kinase (JNK; IC₅₀ = 40 nM for JNK-1 & JNK-2 & 90 nM for JNK-3).
SolubilityDMSO: 15 mg/mL
Assay≥98% (HPLC)
Coloryellow-orange
Formsolid; protect from light
Size5MG, 25MG, 50MG
Storage Conditions-20C
1

An Endogenous Inhibitor of Focal Adhesion Kinase Blocks Rac1/JNK but Not Ras/ERK-dependent Signaling in Vascular Smooth Muscle Cells

Liisa J Sundberg, Lisa M Galante, Heather M Bill, Christopher P Mack, Joan M Taylor

J Biol Chem. 2003 Aug 8;278(32):29783-91.

PMID: 12782622

1

Src and Cas Are Essentially but Differentially Involved in Angiotensin II-stimulated Migration of Vascular Smooth Muscle Cells via Extracellular Signal-Regulated Kinase 1/2 and c-Jun NH2-terminal Kinase Activation

Moe Kyaw, Masanori Yoshizumi, Koichiro Tsuchiya, Shoji Kagami, Yuki Izawa, Yoshiko Fujita, Nermin Ali, Yasuhisa Kanematsu, Kazunori Toida, Kazunori Ishimura, Toshiaki Tamaki

Mol Pharmacol. 2004 Apr;65(4):832-41.

PMID: 15044612

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