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(+/-)-JQ1

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For Research Use Only | Not For Clinical Use
CATAP1268524691
CAS1268524-69-1
MDL NumberMFCD23726614
Molecular Weight456.99
InChI KeyDNVXATUJJDPFDM-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: 2 mg/mL, clear (warmed)
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

Jake E Delmore, Ghayas C Issa, Madeleine E Lemieux, Peter B Rahl, Junwei Shi, Hannah M Jacobs, Efstathios Kastritis, Timothy Gilpatrick, Ronald M Paranal, Jun Qi, Marta Chesi, Anna C Schinzel, Michael R McKeown, etc.

Cell. 2011 Sep 16;146(6):904-17.

PMID: 21889194

1

JQ1: A Novel Potential Therapeutic Target

Xiaoyu Shi, Chen Liu, Baoqing Liu, Juntao Chen, Xiaoying Wu, Weihua Gong

Pharmazie. 2018 Sep 1;73(9):491-493.

PMID: 30223929

1

Protective Effect of the BET Protein Inhibitor JQ1 in Cisplatin-Induced Nephrotoxicity

Liping Sun, Jing Liu, Yanggang Yuan, Xinzhou Zhang, Zheng Dong

Am J Physiol Renal Physiol. 2018 Sep 1;315(3):F469-F478.

PMID: 29767555

1

Selective Inhibition of BET Bromodomains

Panagis Filippakopoulos, Jun Qi, Sarah Picaud, Yao Shen, William B Smith, Oleg Fedorov, Elizabeth M Morse, Tracey Keates, Tyler T Hickman, Ildiko Felletar, Martin Philpott, Shonagh Munro, Michael R McKeown, etc.

Nature. 2010 Dec 23;468(7327):1067-73.

PMID: 20871596

1

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

Jakob Lovén, Heather A Hoke, Charles Y Lin, Ashley Lau, David A Orlando, Christopher R Vakoc, James E Bradner, Tong Ihn Lee, Richard A Young

Cell. 2013 Apr 11;153(2):320-34.

PMID: 23582323

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