CAS 217094-32-1 K-604 - Analytical Products / Alfa Chemistry

CAT	AP217094321
CAS	217094-32-1
Molecular Weight	575.64

Description	≥98% (HPLC)
Solubility	DMSO: 10 mg/mL, clear
Assay	≥98% (HPLC)
Color	white to beige
Size	5MG, 25MG
Storage Conditions	2-8°C

1

A Novel Technical Approach for the Measurement of Individual ACAT-1 and ACAT-2 Enzymatic Activity in the Testis

Li Chen, Julie Lafond, R-Marc Pelletier

Methods Mol Biol. 2009;550:169-77.

PMID: 19495703

1

A Selective ACAT-1 Inhibitor, K-604, Stimulates Collagen Production in Cultured Smooth Muscle Cells and Alters Plaque Phenotype in Apolipoprotein E-knockout Mice

Yasunobu Yoshinaka, Haruki Shibata, Hideyuki Kobayashi, Hiroki Kuriyama, Kimiyuki Shibuya, Sohei Tanabe, Takuya Watanabe, Akira Miyazaki

Atherosclerosis. 2010 Nov;213(1):85-91.

PMID: 20843517

1

A Selective ACAT-1 Inhibitor, K-604, Suppresses Fatty Streak Lesions in Fat-Fed Hamsters Without Affecting Plasma Cholesterol Levels

Mami Ikenoya, Yasunobu Yoshinaka, Hideyuki Kobayashi, Katsumi Kawamine, Kimiyuki Shibuya, Fumiyasu Sato, Kimio Sawanobori, Takuya Watanabe, Akira Miyazaki

Atherosclerosis. 2007 Apr;191(2):290-7.

PMID: 16820149

1

Brain Targeting of Acyl-CoA:Cholesterol

Kimiyuki Shibuya, Shigeru Morikawa, Masayoshi Miyamoto, Shin-Ichiro Ogawa, Yoshihiko Tsunenari, Yasuomi Urano, Noriko Noguchi

ACS Omega. 2019 Oct 2;4(16):16943-16955.

PMID: 31646241

1

Discovery of Clinical Candidate 2-(4-(2-((1 H-Benzo[ d]imidazol-2-yl)thio)ethyl)piperazin-1-yl)- N-(6-methyl-2,4-bis(methylthio)pyridin-3-yl)acetamide Hydrochloride [K-604], an Aqueous-Soluble Acyl-CoA:Cholesterol O-Acyltransferase-1 Inhibitor

Kimiyuki Shibuya, Katsumi Kawamine, Chiyoka Ozaki, Tadaaki Ohgiya, Toshiyuki Edano, Yasunobu Yoshinaka, Yoshihiko Tsunenari

J Med Chem. 2018 Dec 13;61(23):10635-10650.

PMID: 30433781

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