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KB-R7943

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For Research Use Only | Not For Clinical Use
CATALP182004644
CAS182004-64-4 (free base)
MDL NumberMFCD00952138
Molecular Weight427.50
InChI KeyWGIKEBHIKKWJLG-UHFFFAOYSA-N
Description≥98% (HPLC), powder
SolubilityDMSO: >10 mg/mL
Assay≥98% (HPLC)
Coloroff-white to tan
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

KB-R7943 Restores Endothelium-Dependent Relaxation Induced by Advanced Glycosylation End Products in Rat Aorta

Ying Su, Nan Mao, Min Li, Xia Dong, Fan-Zhen Lin, Ying Xu, Yan-Bo Li

J Diabetes Complications. Jan-Feb 2013;27(1):6-10.

PMID: 23021774

1

KB-R7943, a Plasma Membrane Na(+)/Ca(2+) Exchanger Inhibitor, Blocks Opening of the Mitochondrial Permeability Transition Pore

Brian M Wiczer, Raluca Marcu, Brian J Hawkins

Biochem Biophys Res Commun. 2014 Jan 31;444(1):44-9.

PMID: 24434143

1

KB-R7943, an Inhibitor of the Reverse Na+ /Ca2+ Exchanger, Blocks N-methyl-D-aspartate Receptor and Inhibits Mitochondrial Complex I

Tatiana Brustovetsky, Matthew K Brittain, Patrick L Sheets, Theodore R Cummins, Vsevolod Pinelis, Nickolay Brustovetsky

Br J Pharmacol. 2011 Jan;162(1):255-70.

PMID: 20883473

1

Paradoxical Effects of KB-R7943 on Arrhythmogenicity in a Chronic Myocardial Infarction Rabbit Model

Po-Cheng Chang, Hung-Ta Wo, Hui-Ling Lee, Ming-Shien Wen, Chung-Chuan Chou

J Cardiol. 2015 Jul;66(1):80-7.

PMID: 25241015

1

The Reverse-Mode NCX1 Activity Inhibitor KB-R7943 Promotes Prostate Cancer Cell Death by Activating the JNK Pathway and Blocking Autophagic Flux

Zhou Long, BaiJun Chen, Qian Liu, Jiang Zhao, ZhenXing Yang, XingYou Dong, LiuBin Xia, ShengQuan Huang, XiaoYan Hu, Bo Song, LongKun Li

Oncotarget. 2016 Jul 5;7(27):42059-42070.

PMID: 27275542

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