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KML29

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For Research Use Only | Not For Clinical Use
CATAP1380424429
CAS1380424-42-9
MDL NumberMFCD22987957
Molecular Weight549.42
Description≥98% (HPLC)
SolubilityDMSO: 2 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

Combatting Joint Pain and Inflammation by Dual Inhibition of Monoacylglycerol Lipase and cyclooxygenase-2 in a Rat Model of Osteoarthritis

Holly T Philpott, Jason J McDougall

Arthritis Res Ther. 2020 Jan 14;22(1):9.

PMID: 31937359

1

Comparative Biochemical Characterization of the Monoacylglycerol Lipase Inhibitor KML29 in Brain, Spinal Cord, Liver, Spleen, Fat and Muscle Tissue

Noemi Pasquarelli, Christoph Porazik, Johannes Hanselmann, Patrick Weydt, Boris Ferger, Anke Witting

Neuropharmacology. 2015 Apr;91:148-56.

PMID: 25497453

1

Contrasting Effects of Selective MAGL and FAAH Inhibition on Dopamine Depletion and GDNF Expression in a Chronic MPTP Mouse Model of Parkinson's Disease

Noemi Pasquarelli, Christoph Porazik, Hanna Bayer, Eva Buck, Stefan Schildknecht, Patrick Weydt, Anke Witting, Boris Ferger

Neurochem Int. 2017 Nov;110:14-24.

PMID: 28826718

1

In Vivo Characterization of the Highly Selective Monoacylglycerol Lipase Inhibitor KML29: Antinociceptive Activity Without Cannabimimetic Side Effects

B M Ignatowska-Jankowska, S Ghosh, M S Crowe, S G Kinsey, M J Niphakis, R A Abdullah, Q Tao, S T O' Neal, D M Walentiny, J L Wiley, B F Cravatt, A H Lichtman

Br J Pharmacol. 2014 Mar;171(6):1392-407.

PMID: 23848221

1

The Monoacylglycerol Lipase Inhibitor KML29 With Gabapentin Synergistically Produces Analgesia in Mice

Molly S Crowe, Catheryn D Wilson, Emma Leishman, Paul L Prather, Heather B Bradshaw, Matthew L Banks, Steven G Kinsey

Br J Pharmacol. 2017 Dec;174(23):4523-4539.

PMID: 28963716

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