CAS 127191-97-3 KN-62 - Analytical Products / Alfa Chemistry

CAT	AP127191973-A
CAS	127191-97-3
Structure
MDL Number	MFCD00083180
Molecular Weight	721.84
InChI Key	RJVLFQBBRSMWHX-DHUJRADRSA-N

Description	≥95%, powder
Solubility	45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.93 mg/mL; methanol: 10 mg/mL; DMSO: 12 mg/mL; chloroform: 20 mg/mL
Assay	≥95%
Color	yellow
Form	powder
Size	0.5MG, 1MG
Storage Conditions	−20°C

1

CaMKII Inhibitor KN-62 Blunts Tumor Response to Hypoxia by Inhibiting HIF-1α in Hepatoma Cells

Kyoung-Hwa Lee

Korean J Physiol Pharmacol. 2010 Oct;14(5):331-6.

PMID: 21165333

1

Effect of KN-62, a Selective Inhibitor of Calmodulin-Dependent Kinase II, on Mouse Oocyte Activation

N Inagaki, S Suzuki, H Kitai, N Nakatogawa, N Kuji, K Iwahashi, Y Yoshimura

J Assist Reprod Genet. 1997 Nov;14(10):609-16.

PMID: 9447464

1

KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi Ne, a Specific Inhibitor of Ca2+/calmodulin-dependent Protein Kinase II

H Tokumitsu, T Chijiwa, M Hagiwara, A Mizutani, M Terasawa, H Hidaka

J Biol Chem. 1990 Mar 15;265(8):4315-20.

PMID: 2155222

1

KN-62, a Specific Ca++/calmodulin-dependent Protein Kinase Inhibitor, Reversibly Depresses the Rate of Beating of Cultured Fetal Mouse Cardiac Myocytes

K Okazaki, T Ishikawa, M Inui, M Tada, K Goshima, T Okamoto, H Hidaka

J Pharmacol Exp Ther. 1994 Sep;270(3):1319-24.

PMID: 7932185

1

The Isoquinoline Derivative KN-62 a Potent Antagonist of the P2Z-receptor of Human Lymphocytes

C E Gargett, J S Wiley

Br J Pharmacol. 1997 Apr;120(8):1483-90.

PMID: 9113369

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