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KN-62 - CAS 127191-97-3

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For Research Use Only | Not For Clinical Use
CATAP127191973-B
CAS127191-97-3
Structure
Molecular Weight721.84
DescriptionA cell-permeable, reversible, and selective inhibitor of CaM kinase II (Ki = 900 nM for rat brain CaM kinase II) that binds directly to the calmodulin binding site of the enzyme.
Solubilitymethanol: 5 mg/mL; DMSO: soluble
Assay≥95% (HPLC)
Coloroff-white
Formsolid; desiccated; protect from light
Size1MG
Storage Conditions+2C to +8C
1

Synthesis, Biological Activity and Molecular Modeling Studies of 1,2,3,4-tetrahydroisoquinoline Derivatives as Conformationally Constrained Analogues of KN62, a Potent Antagonist of the P2X7-receptor Containing a Tyrosine Moiety

Pier Giovanni Baraldi, Rimma Makaeva, Maria Giovanna Pavani, Maria del Carmen Nuñez, Giampiero Spalluto, Stefano Moro, Simonetta Falzoni, Francesco Di Virgilio, Romeo Romagnoli

Arzneimittelforschung. 2002;52(4):273-85.

PMID: 12040970

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