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KN-93

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For Research Use Only | Not For Clinical Use
CATAP139298401-B
CAS139298-40-1
Structure
MDL NumberMFCD03788201
Molecular Weight599.03
InChI KeyNNKJTPOXLIILMB-IPZCTEOASA-N
Description≥98% (HPLC)
SolubilityDMSO: 1 mg/mL; H2O: soluble
Assay≥98% (HPLC)
Colorwhite
Size0.1MG, 0.5MG
Storage Conditions2-8°C
1

Assessment of the Protective Effect of KN-93 Drug in Systemic Epilepsy Disorders Induced by Pilocarpine in Male Rat

Fatemeh Ebrahimi, Seyed Shahabeddin Sadr, Mehrdad Roghani, Safoura Khamse, Saeed Mohammadian Haftcheshmeh, Mojdeh Navid Hamidi, Parvaneh Mohseni-Moghaddam, Elham Zamani

J Cell Biochem. 2019 Sep;120(9):15906-15914.

PMID: 31074121

1

KN-93 (2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent Protein Kinase II Inhibitor, Is a Direct Extracellular Blocker of Voltage-Gated Potassium Channels

Saman Rezazadeh, Thomas W Claydon, David Fedida

J Pharmacol Exp Ther. 2006 Apr;317(1):292-9.

PMID: 16368898

1

KN-93 Inhibits IKr in Mammalian Cardiomyocytes

Bence Hegyi, Ye Chen-Izu, Zhong Jian, Rafael Shimkunas, Leighton T Izu, Tamas Banyasz

J Mol Cell Cardiol. 2015 Dec;89(Pt B):173-6.

PMID: 26463508

1

KN-93, a Specific Inhibitor of CaMKII Inhibits Human Hepatic Stellate Cell Proliferation in Vitro

Ping An, Jun-Yong Zhu, Yan Yang, Peng Lv, Yi-Hao Tian, Ming-Kai Chen, He-Sheng Luo

World J Gastroenterol. 2007 Mar 7;13(9):1445-8.

PMID: 17457979

1

The KN-93 Molecule Inhibits Calcium/Calmodulin-Dependent Protein Kinase II (CaMKII) Activity by Binding to Ca 2+/CaM

Melanie H Wong, Alexandra B Samal, Mike Lee, Jiri Vlach, Nikolai Novikov, Anita Niedziela-Majka, Joy Y Feng, Dmitry O Koltun, Katherine M Brendza, Hyock Joo Kwon, Brian E Schultz, Roman Sakowicz, Jamil S Saad, etc.

J Mol Biol. 2019 Mar 29;431(7):1440-1459.

PMID: 30753871

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