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Kobe0065

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For Research Use Only | Not For Clinical Use
CATAP436133685
CAS436133-68-5
Molecular Weight449.79
Description≥98% (HPLC)
SolubilityDMSO: 15 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

Discovery of Small-Molecule Ras Inhibitors That Display Antitumor Activity by Interfering With Ras·GTP-effector Interaction

Fumi Shima, Yoko Yoshikawa, Shigeyuki Matsumoto, Tohru Kataoka

Enzymes. 2013;34 Pt. B:1-23.

PMID: 25034098

1

Glycyrrhetinic Acid Binds to the Conserved P-loop Region and Interferes With the Interaction of RAS-effector Proteins

Yuan Zhang, Zhihua Wang, Xiaoyao Ma, Shengnan Yang, Xueyan Hu, Jin Tao, Yuanyuan Hou, Gang Bai

Acta Pharm Sin B. 2019 Mar;9(2):294-303.

PMID: 30976491

1

In Silico Discovery of Small-Molecule Ras Inhibitors That Display Antitumor Activity by Blocking the Ras-effector Interaction

Fumi Shima, Yoko Yoshikawa, Min Ye, Mitsugu Araki, Shigeyuki Matsumoto, Jingling Liao, Lizhi Hu, Takeshi Sugimoto, Yuichi Ijiri, Azusa Takeda, Yuko Nishiyama, Chie Sato, Shin Muraoka, Atsuo Tamura, Tsutomu Osoda, etc.

Proc Natl Acad Sci U S A. 2013 May 14;110(20):8182-7.

PMID: 23630290

1

Ras Inhibitors Display an Anti-Metastatic Effect by Downregulation of Lysyl Oxidase Through Inhibition of the Ras-PI3K-Akt-HIF-1α Pathway

Yoko Yoshikawa, Osamu Takano, Ichiro Kato, Yoshihisa Takahashi, Fumi Shima, Tohru Kataoka

Cancer Lett. 2017 Dec 1;410:82-91.

PMID: 28951129

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