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KRCA-0008

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For Research Use Only | Not For Clinical Use
CATAP1472795202
CAS1472795-20-2
Molecular Weight609.12
Description≥98% (HPLC)
SolubilityDMSO: 20 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to brown
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

ALK Inhibitors of Bis-Ortho-Alkoxy-Para-Piperazinesubstituted-Pyrimidines and -Triazines for Cancer Treatment

Hyeon Ji Lee, Muhammad Latif, Hyeonjeong Choe, Imran Ali, Heung Kyoung Lee, Eun Hye Yang, Jeong In Yun, Chong Hak Chae, Jae-Kyung Jung, Hyoung Rae Kim, Chong Ock Lee, Chi Hoon Park, Kwangho Lee

Arch Pharm Res. 2014;37(9):1130-8.

PMID: 24446111

1

Development of Potent ALK Inhibitor and Its Molecular Inhibitory Mechanism Against NSCLC Harboring EML4-ALK Proteins

Chung Hyo Kang, Jeong In Yun, Kwangho Lee, Chong Ock Lee, Heung Kyoung Lee, Chang-Soo Yun, Jong Yeon Hwang, Sung Yun Cho, Heejung Jung, Pilho Kim, Jae Du Ha, Jeong Hee Jeon, Sang Un Choi, Hye Gwang Jeong, etc.

Biochem Biophys Res Commun. 2015 Aug 28;464(3):762-7.

PMID: 26168728

1

KRCA-0008 Suppresses ALK-positive Anaplastic Large-Cell Lymphoma Growth

Jungjoong Hwang, Insuk Song, Kwangho Lee, Hyoung Rae Kim, Eun-Hye Hong, Jung Soon Hwang, Sung-Hoon Ahn, Jongkook Lee

Invest New Drugs. 2020 Jan 20.

PMID: 31956933

1

Novel bis-ortho-alkoxy-para-piperazinesubstituted-2,4-dianilinopyrimidines (KRCA-0008) as Potent and Selective ALK Inhibitors for Anticancer Treatment

Chi Hoon Park, Hyeonjeong Choe, In-Young Jang, So Yeong Kwon, Muhammad Latif, Heung Kyoung Lee, Hyeon Ji Lee, Eun Hye Yang, Jeong In Yun, Chong Hak Chae, Sung Yun Cho, Sang Un Choi, Jae Du Ha, Heejung Jung, etc.

Bioorg Med Chem Lett. 2013 Nov 15;23(22):6192-6.

PMID: 24095090

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