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KU-0060648

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For Research Use Only | Not For Clinical Use
CATAP881375004
CAS881375-00-4
MDL NumberMFCD17214218
Molecular Weight582.71
InChI KeyAATCBLYHOUOCTO-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: 1 mg/mL, clear (warmed)
Assay≥98% (HPLC)
Colorwhite to light brown
Formpowder
Size5MG, 25MG
Storage Conditions−20°C
1

Chemosensitization of Cancer Cells by KU-0060648, a Dual Inhibitor of DNA-PK and PI-3K

Joanne M Munck, Michael A Batey, Yan Zhao, Helen Jenkins, Caroline J Richardson, Celine Cano, Michele Tavecchio, Jody Barbeau, Julia Bardos, Liam Cornell, Roger J Griffin, Keith Menear, Andrew Slade, Pia Thommes, etc.

Mol Cancer Ther. 2012 Aug;11(8):1789-98.

PMID: 22576130

1

Feedback Autophagy Activation as a Key Resistance Factor of Ku-0060648 in Colorectal Cancer Cells

Mintao Mao, Yumei Liu, Xinhai Gao

Biochem Biophys Res Commun. 2017 Sep 2;490(4):1244-1249.

PMID: 28676397

1

KU-0060648 Inhibits Hepatocellular Carcinoma Cells Through DNA-PKcs-dependent and DNA-PKcs-independent Mechanisms

Min-Bin Chen, Zhen-Tao Zhou, Lan Yang, Mu-Xin Wei, Min Tang, Ting-Yan Ruan, Jun-Ying Xu, Xiao-Zhong Zhou, Gang Chen, Pei-Hua Lu

Oncotarget. 2016 Mar 29;7(13):17047-59.

PMID: 26933997

1

Pharmacological Inhibition of DNA-PK Stimulates Cas9-mediated Genome Editing

Francis Robert, Mathilde Barbeau, Sylvain Éthier, Josée Dostie, Jerry Pelletier

Genome Med. 2015 Aug 27;7(1):93.

PMID: 26307031

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