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KU-60019

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For Research Use Only | Not For Clinical Use
CATAP925701491
CAS925701-49-1
MDL NumberMFCD19690944
Molecular Weight547.67
InChI KeySCELLOWTHJGVIC-BGYRXZFFSA-N
Description≥98% (HPLC)
SolubilityDMSO: 20 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions−20°C
1

Alleviation of Senescence via ATM Inhibition in Accelerated Aging Models

Myeong Uk Kuk, Jae Won Kim, Young-Sam Lee, Kyung A Cho, Joon Tae Park, Sang Chul Park

Mol Cells. 2019 Mar 31;42(3):210-217.

PMID: 30726661

1

ATM in DNA Repair in Cancer

Mei Hua Jin, Do-Youn Oh

Pharmacol Ther. 2019 Nov;203:107391.

PMID: 31299316

1

Chemical Screening Identifies ATM as a Target for Alleviating Senescence

Hyun Tae Kang, Joon Tae Park, Kobong Choi, Yongsub Kim, Hyo Jei Claudia Choi, Chul Won Jung, Young-Sam Lee, Sang Chul Park

Nat Chem Biol. 2017 Jun;13(6):616-623.

PMID: 28346404

1

Improved ATM Kinase Inhibitor KU-60019 Radiosensitizes Glioma Cells, Compromises Insulin, AKT and ERK Prosurvival Signaling, and Inhibits Migration and Invasion

Sarah E Golding, Elizabeth Rosenberg, Nicholas Valerie, Isa Hussaini, Mark Frigerio, Xiaoling F Cockcroft, Wei Yee Chong, Marc Hummersone, Laurent Rigoreau, Keith A Menear, Mark J O'Connor, Lawrence F Povirk, etc.

Mol Cancer Ther. 2009 Oct;8(10):2894-902.

PMID: 19808981

1

Predictability, Efficacy and Safety of Radiosensitization of Glioblastoma-Initiating Cells by the ATM Inhibitor KU-60019

Donatella Vecchio, Antonio Daga, Elisa Carra, Daniela Marubbi, Gabriella Baio, Carlo E Neumaier, Stefano Vagge, Renzo Corvò, Maria Pia Brisigotti, Jean Louis Ravetti, Annalisa Zunino, Alessandro Poggi, etc.

Int J Cancer. 2014 Jul 15;135(2):479-91.

PMID: 24443327

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