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KYP-2047

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For Research Use Only | Not For Clinical Use
CATAP796874992
CAS796874-99-2
MDL NumberMFCD22201003
Molecular Weight339.43
InChI KeySPXFAUXQZWJGCJ-ROUUACIJSA-N
Description≥95% (HPLC)
Assay≥95% (HPLC)
Colorwhite to light brown
Formoil
Size5MG, 25MG
Storage Conditions2-8°C
1

A Prolyl Oligopeptidase Inhibitor, KYP-2047, Reduces α-synuclein Protein Levels and Aggregates in Cellular and Animal Models of Parkinson's Disease

T T Myöhänen, M J Hannula, R Van Elzen, M Gerard, P Van Der Veken, J A García-Horsman, V Baekelandt, P T Männistö, A M Lambeir

Br J Pharmacol. 2012 Jun;166(3):1097-113.

PMID: 22233220

1

Brain Pharmacokinetics of Two Prolyl Oligopeptidase Inhibitors, JTP-4819 and KYP-2047, in the Rat

Aaro J Jalkanen, Jenni J Hakkarainen, Marko Lehtonen, Tetta Venäläinen, Tiina M Kääriäinen, Elina Jarho, Marjukka Suhonen, Markus M Forsberg

Basic Clin Pharmacol Toxicol. 2011 Dec;109(6):443-51.

PMID: 21707925

1

Inhibition of Prolyl Oligopeptidase by KYP-2047 Fails to Increase the Extracellular Neurotensin and Substance P Levels in Rat Striatum

Aaro J Jalkanen, Katja Savolainen, Markus M Forsberg

Neurosci Lett. 2011 Sep 15;502(2):107-11.

PMID: 21820035

1

KYP-2047 Penetrates Mouse Brain and Effectively Inhibits Mouse Prolyl Oligopeptidase

Aaro J Jalkanen, Juuso V Leikas, Markus M Forsberg

Basic Clin Pharmacol Toxicol. 2014 Jun;114(6):460-3.

PMID: 24350801

1

The Beneficial Effect of a Prolyl Oligopeptidase Inhibitor, KYP-2047, on Alpha-Synuclein Clearance and Autophagy in A30P Transgenic Mouse

Mari H Savolainen, Christopher T Richie, Brandon K Harvey, Pekka T Männistö, Kathleen A Maguire-Zeiss, Timo T Myöhänen

Neurobiol Dis. 2014 Aug;68:1-15.

PMID: 24746855

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