CAS 292632-98-5 L-685,458 - Analytical Products / Alfa Chemistry

CAT	AP292632985
CAS	292632-98-5
Structure
MDL Number	MFCD03093402
Molecular Weight	672.85
InChI Key	MURCDOXDAHPNRQ-ZJKZPDEISA-N

Description	>96% (HPLC), solid
Solubility	DMSO: >10 mg/mL
Assay	>96% (HPLC)
Color	white
Form	solid
Size	1MG, 5MG
Storage Conditions	−20°C

1

[3H]-L-685,458 as a Radiotracer That Maps Gamma-Secretase Complex in the Rat Brain: Relevance to Abeta Genesis and Presence of Active presenilin-1 Components

Kun Xiong, Richard W Clough, Xue-Gang Luo, Robert G Struble, Yue-Ming Li, Xiao-Xin Yan

Brain Res. 2007 Jul 9;1157:81-91.

PMID: 17512915

1

Gamma-secretase Inhibitors Exerts Antitumor Activity via Down-Regulation of Notch and Nuclear Factor Kappa B in Human Tongue Carcinoma Cells

J Yao, L Duan, M Fan, X Wu

Oral Dis. 2007 Nov;13(6):555-63.

PMID: 17944672

1

L-685,458, an Aspartyl Protease Transition State Mimic, Is a Potent Inhibitor of Amyloid Beta-Protein Precursor Gamma-Secretase Activity

M S Shearman, D Beher, E E Clarke, H D Lewis, T Harrison, P Hunt, A Nadin, A L Smith, G Stevenson, J L Castro

Biochemistry. 2000 Aug 1;39(30):8698-704.

PMID: 10913280

1

Specificity of presenilin-1- And presenilin-2-dependent γ-secretases Towards Substrate Processing

Serena Stanga, Céline Vrancx, Bernadette Tasiaux, Claudia Marinangeli, Helena Karlström, Pascal Kienlen-Campard

J Cell Mol Med. 2018 Feb;22(2):823-833.

PMID: 28994238

1

Uncovering the Binding Mode of γ -Secretase Inhibitors

Manuel Hitzenberger, Martin Zacharias

ACS Chem Neurosci. 2019 Aug 21;10(8):3398-3403.

PMID: 31244051

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