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LDN-212854

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For Research Use Only | Not For Clinical Use
CATAP1432597266
CAS1432597-26-6
Molecular Weight406.48
Description≥98% (HPLC)
SolubilityDMSO: 1 mg/mL, clear (warmed)
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

Activin A Receptor Type 1-mediated BMP Signaling Regulates RANKL-induced Osteoclastogenesis via Canonical SMAD-signaling Pathway

Maiko Omi, Vesa Kaartinen, Yuji Mishina

J Biol Chem. 2019 Nov 22;294(47):17818-17836.

PMID: 31619522

1

Development of an ALK2-biased BMP Type I Receptor Kinase Inhibitor

Agustin H Mohedas, Xuechao Xing, Kelli A Armstrong, Alex N Bullock, Gregory D Cuny, Paul B Yu

ACS Chem Biol. 2013;8(6):1291-302.

PMID: 23547776

1

Strategic Targeting of Multiple BMP Receptors Prevents Trauma-Induced Heterotopic Ossification

Shailesh Agarwal, Shawn J Loder, Christopher Breuler, John Li, David Cholok, Cameron Brownley, Jonathan Peterson, Hsiao H Hsieh, James Drake, Kavitha Ranganathan, Yashar S Niknafs, Wenzhong Xiao, Shuli Li, etc.

Mol Ther. 2017 Aug 2;25(8):1974-1987.

PMID: 28716575

1

Structural Basis for the Potent and Selective Binding of LDN-212854 to the BMP Receptor Kinase ALK2

Eleanor Williams, Alex N Bullock

Bone. 2018 Apr;109:251-258.

PMID: 28918311

1

Two Tissue-Resident Progenitor Lineages Drive Distinct Phenotypes of Heterotopic Ossification

Devaveena Dey, Jana Bagarova, Sarah J Hatsell, Kelli A Armstrong, Lily Huang, Joerg Ermann, Ashley J Vonner, Yue Shen, Agustin H Mohedas, Arthur Lee, Elisabeth M W Eekhoff, Annelies van Schie, Marie B Demay, etc.

Sci Transl Med. 2016 Nov 23;8(366):366ra163.

PMID: 27881824

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